Phylogenomics and population genomics of SARS-CoV-2 in Mexico during the pre-vaccination stage reveals variants of interest B.1.1.28.4 and B.1.1.222 or B.1.1.519 and the nucleocapsid mutation S194L associated with symptoms.
Result: Our samples contained SNVs in one of the early strain types (VI) that spread out of China (C241T, C3037T, C14408T and A23403G mutations) which has the haplotype of allelic associations 241T-3037T-14408T-23403G, detected in high frequency worldwide (December 2020), and that may be involved in increasing the fitness of the SARS-CoV-2 virus.
Characterization of altered genomic landscape of SARS-CoV-2 variants isolated in Saudi Arabia in a comparative in silico study.
PMID: 34866979
2021
Saudi journal of biological sciences
Conclusion: The SARS CoV-2 variants iso
Result: Our analysis showed that the most frequently changed nucleotide were C3037T (silent mutation) and A23403G (D614G) each of which occurred in 57 variants out of 58, followed by C14408T (P4715L) and C241T (5'UTR) which were found in 56 and 55 variants, respectively.
Result: The coexistence of C241T (5'UTR), C3037T (ORF1ab), C14408T (ORF1ab) and A23403G (S gene) was observed in 55 variants.
Mutational landscape of SARS-CoV-2 genome in Turkey and impact of mutations on spike protein structure.
Result: Eight single nucleotide polymorphisms (SNPs) were identified, including C242T, C313T, C3037T, C14408T, A23403G, G28881A, G28882A, and G28883C.
Discussion: A total of eight bases in the viral RNA sequence were mutated (referred to as: Gene Bank ID: MW301121) as follows: C241T, C313T, C3037T, C14408T, A23403G, and GGG28881AAC.
Discussion: We determined the Sichuan-2020 sequence belongs to haplogroup A2a4 (diagnostic variants: C241T<
Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody Treatment.
Abstract: Among such variants, 23403A>G variant (p.D614G) in spike protein B-cell epitope is observed frequently in European countries, such as the Netherlands, Switzerland, and France, but seldom observed in China.
Conclusion: The highly prevalent 23403A>G (p.D614G) variant in the European population may cause antigenic drift, resulting in vaccine mismatches that offer little protection to that group of patients.
Method: Additionally, country-based statistics of the prevalence of 23403A>G variant (p.D614G) were generated, as shown in Table 2.
Result: Among the twelve variants in the B-cell epitopes, 23403A>G variant
Molecular Detection of SARS-CoV-2 Infection in FFPE Samples and Histopathologic Findings in Fatal SARS-CoV-2 Cases.
PMID: 32451533
2020
American journal of clinical pathology
Discussion: Sequencing of viral RNA from FFPE lung tissue from the case 1 autopsy showed mutations most consistent with a subset of the Western European Clade A2a (C3037T, C14408T, A23403G), with mutations enriched in New York State A2a cases (C1059T and G25563T).
Analysis of RNA sequences of 3636 SARS-CoV-2 collected from 55 countries reveals selective sweep of one virus type.
PMID: 32474553
2020
The Indian journal of medical research
Introduction: Another mutation, A23403G, located in the gene encoding the spike glycoprotein results in an amino acid change (D614G) from aspartic acid to glycine.
An updated analysis of variations in SARS-CoV-2 genome.
Abstract: Despite some variations being in low frequency rate in some continents, C14408T and A23403G variations on Nsp12 and S protein, respectively, observed to be the most prominent variations all over the world, in general, and both cause missense mutations.
Result: A23403G variation is one of the most important variations that have been reported previously (Phan et al., 2020) caused D614G substitution on S protein.
Result: As in the C14408T of Nsp12 variation, A23403G variation of S protein is also available in 70.46% frequency in SARS-CoV-2 genomes isolated all over the world (Fi
Identification of the nucleotide substitutions in 62 SARS-CoV-2 sequences from Turkey.
Discussion: A23403G mutation in the spike glycoprotein coding region was also amongst the mostly seen mutations in viral isolates from Turkey (61%).
Discussion: A23403G substitution was found to be present in isolates from Europe and leads to an amino acid change from aspartate to glycine at position 614 (D614G) within the spike glycoprotein, where these amino acids differ by means of their isoelectric points (Pachetti et al., 2020).
Discussion: According to the linkage analysis, C241T, C3037T, C14408T and A23403G in Cluster 3 were in complete linkage and the TTTG h
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Result: At the end of January 2020, a nonsynonymous nucleotide change from the ancestral virus, A23403G, first appeared in virus genomes reported in China (hCoV-19/Zhejiang/HZ103/2020; 24 January 2020) and in Germany (hCoV-19/Germany/BavPat1-ChVir929/2020; 28 January 2020).
SARS_CoV_2 mutation literature information.
PMID: 
2021
Microbial genomics
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