literature

SARS_CoV_2 mutation literature information.

Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike's Dynamics.

PMID: 34064904 2021 Viruses

Result: During phase 1, three Nextstrain clade 20A variants (C3037T, C14408T, and A23403G) were identified, which accounted for 43.3% of cases.

AutoVEM: An automated tool to real-time monitor epidemic trends and key mutations in SARS-CoV-2 evolution.

PMID: 33841748 2021 Computational and structural biotechnology journal

Result: Among the prevalent haplotype subgroups, H5, H7, H9 and H11 all had A23403G mutations, which indicated that the single A23403G mutation was related to infectivity, pathogenicity or host adaptability of SARS-CoV-2, while H10 had the other three specific mutations, including C241T, C3037T and C14408T, indicating that the combined mutations of these 3 sites also had a certain impact on infectivity, pathogenicity or host adaptability of SARS-CoV-2.

Result: Among these 23 sites, except for the 4 specific sites (C241T C3037T C14408T and A23403G) of the previous H1 haplotype with mutation frequency greater than 0.8, only the above 6 mutation sites of high

SARS-CoV-2 mutations: the biological trackway towards viral fitness.

PMID: 33928885 2021 Epidemiology and infection

Introduction: Cluster I includes 3037C>T; NSP3:F106F (non-structural protein3:F106F) and 14408C>T; RdRp:P323L, cluster II includes 3037C>T, 14408C>T and 23403A>G; S:D614G, cluster III includes 14408C>T, cluster IV includes 3037C>T, 14408C>T, 23403A>G, 28881G>A; N:R203K, 28882G>A

Emergence in southern France of a new SARS-CoV-2 variant harbouring both N501Y and E484K substitutions in the spike protein.

PMID: 33991677 2021 Clinical microbiology and infection

Result: In addition, sequences that span codons 1-618 of the spike gene and allow the identification of this variant by covering 4 of its hallmark mutations (C21614T (substitution L18F), G22468T, T22917G (L452R), A23063T (N501Y)) and by being devoid of the Nextstrain clade 20 A23403G mutation, were obtained for 43 other patients (deposited at: https://doi.org/10.35081/43r6-sz33).

Genomic epidemiology of SARS-CoV-2 in Esteio, Rio Grande do Sul, Brazil.

PMID: 34016042 2021 BMC genomics

Result: All B.1.1.248 sequences shared C241T (5 UTR), C3037T (ORF1ab nsp3:F924), C12053T (ORF1ab nsp7:L3930F), C14408T (ORF1ab RdRp:L4715), A23403G (S:D614G), G25088T (S:V1176F), and GGG28881-28883AAC (N:RG203-204KR) replacements.

Result: High frequency (>5 genomes) missense mutations were observed in the following posi

SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains.

PMID: 34033650 2021 PloS one

Introduction: We were the first to report the major role of D614G (23403A>G) mutation located at the S1-S2 proximal junction.

Genome-wide analysis of SARS-CoV-2 strains circulating in Vietnam: Understanding the nature of the epidemic and role of the D614G mutation.

PMID: 34042186 2021 Journal of medical virology

Discussion: Eighteen samples had the signature mutation profile of A23403G which was related to the amino acid change, D614G.

Discussion: There were three alterations in the spike region: A23403G, C23731T, and G24794T.

High-resolution melting curve FRET-PCR rapidly identifies SARS-CoV-2 mutations.

PMID: 34138474 2021 Journal of medical virology

Abstract: Reverse transcription fluorescence resonance energy transfer-polymerase chain reaction (FRET-PCRs) were designed against the two most common mutations in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) (A23403G in the spike protein; C14408T in the RNA-dependent RNA polymerase).

Method: Genomic RNA of two SARS-CoV-2 viruses from american type culture collection (ATCC) served as controls and as quantitative standards: 2019-nCOV/USA-WA1/2020 which does not contain the A23403G and the C14408T mutations, and 201/501Y.V1 which contains both mutations.

Method: The 6-carboxyfluorescein (6-FAM)-labeled probes were further designed to contain the unique A23403G or

PMID: 34128696 2021 mSystems

Introduction: This variant contains a mutation from A to G at nucleotide 23403, resulting in amino acid change from aspartic acid to glycine at residue 614 of the spike protein, which appeared to increase viral infectivity and transmissibility.

Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.

PMID: 34103090 2021 European journal of medical research

Abstract: Studies have demonstrated that the C14408T and A23403G alterations in the Nsp12 and S proteins are the most prominent alterations in the world, leading to life-threatening mutations.The spike D614G amino acid change has become the most common variant since December 2019.

Result: Studies have demonstrated that the C14408T and A23403G alterations in the Nsp12 and S proteins are the most prominent alterations in the world, leading to miserable mutations.The spike D614G amino acid change has become the most common variant since December 2019.|mgd

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