Result: The effects of mutations on the protein sequences of SARS-CoV-2 highlighted similar profiles in the North African countries with a mutation affecting the nucleotide adenosine in position (23,403) transformed into a guanosine (A23403G) causing a D614G spike (S) variant as the most common amino acid change occurring in 1553 (95.27%) of total SARS-CoV-2 genomes.
Discussion: However, the A23403G mutation leading to the D614G spike (S) variant was found to be located in a heavily glycosylated residue in the viral spike, was implicated in increased infectiveness and allows fast spreading of the virus during the COVID-19 pande
High-resolution melting analysis after nested PCR for the detection of SARS-CoV-2 spike protein G339D and D796Y variations.
PMID: 35349821
2022
Biochemical and biophysical research communications
Introduction: reported the detection of D614G (nucleotide mutation: A23403G) and L452R (nucleotide mutation: T22917G) variations in the SARS-CoV-2 spike protein by post-PCR HRM analysis, respectively.
Discussion: In the case of detection for the D614G variation (mutation A23403G) reported by Gazali et al., the difference in the Tm value was 0.23 C.
Circulation of SARS-CoV-2 Variants among Children from November 2020 to January 2022 in Trieste (Italy).
Result: Finally, 1/32 sequence was the Omicron strain, with the following mutations in the RBD domain: T22882G (N440K), G22898A (G446S), G22992A (S477N), C22995A (T478K), A23013C (E484A), A23040G (Q493R), G23048A (G496S), A23055G (Q498R), A23063T (N501Y), T23075C ( PMID: 35369437
2022
Frontiers in microbiology
Abstract: A total of 328 nucleotide mutation sites were found in 42 genomes, among which A23403G mutation (D614G amino acid change in the spike protein) was the most common substitution.
Result: To other sequences except 200327-84, 200328-142 and 200328-143, the D614G amino acid change in the S protein occurred by an A23403G nucleotide mutation, which confirmed to be associated with greater infectivity (Figure 2B).
Clinico-Genomic Analysis Reiterates Mild Symptoms Post-vaccination Breakthrough: Should We Focus on Low-Frequency Mutations?
In-silico genomic landscape characterization and evolution of SARS-CoV-2 variants isolated in India shows significant drift with high frequency of mutations.
PMID: 35233173
2022
Saudi journal of biological sciences
Discussion: A23403G (D614G) was observed in West European states in the early stage of the disease and this finding might point towards the source of infection from which it was introduced in India.
Discussion: Moreover, the present study showed that A23403G (D614G) co-occurred with three other mutations that were C241T, C14408T, and C3037T, a similar pattern of co-existence was reported by, while observed the co-existent of C14408T and A23403G.
Discussion: The most frequent nonsynonymous mutation in our study occurred in the S gene at the position A23403G where A changed to G leading t
Emergence of Progressive Mutations in SARS-CoV-2 From a Hematologic Patient With Prolonged Viral Replication.
Result: The patient presented 6 nucleotide mutations and 2 amino acid changes from the reference sequence Wuhan-1 (GenBank accession number: NC_045512): C96T, C241T, G12769T, C14408T, A20268G, A23403G, being present in the 12 consensus sequences analyzed from the patient.
Genomic monitoring unveil the early detection of the SARS-CoV-2 B.1.351 (beta) variant (20H/501Y.V2) in Brazil.
Abstract: Apart from that the group of SNVs became dominant, which is represented by two nonsynonymous mutations A23403G (S:D614G) and C14408T (ORF1ab:P4715L), a few emerging groups of SNVs were recognized with sharply increased monthly incidence ratios of up to 70% in November 2020.
Introduction: The majority of SARS-CoV-2 genomes have evolved with a dominant SNV cluster represented by nonsynonymous mutations Result: It is not surprising to see that group A of SNVs has prevailed since June 2020, represented by A23403G (S:D614G) and C14408T (OFR1ab:P4715L).
SARS_CoV_2 mutation literature information.
PMID: 
2022
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