Abstract: To date, type VI, characterized by the four signature SNVs C241T (5'UTR), C3037T (nsp3 F924F), C14408T (nsp12 P4715L), and A23403G (Spike D614G), with strong allelic associations, has become the dominant type.
Method: It is noteworthy that we observed two nucleotides with a nonnegligible variation frequency relative to their neighboring regions: 1) C241T (5' UTR) with a variation frequency of 45.5% (and this nucleotide was in high allelic association with C3037T
Genetic diversity of SARS-CoV-2 and clinical, epidemiological characteristics of COVID-19 patients in Hanoi, Vietnam.
Abstract: The three most common variants were linked, and included C3037T, C14408T (nsp12: P323L) and A23403G (
Result: The most ubiquitous modifications were C3037T, C14408T (P323L) and A23403G (D614G) occurring in 40/44 samples.
Result: These variants are key markers to define lineages B.1 (C241T, C3037T, A23403G) and B.1.1 (C241T, C3037T, A23403G, GGG28881..28883AAC), the major lineages in our study.
Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity.
Result: Among the common variants, the most frequent mutations are 23403 A > G (D614G, S gene), 241 C > T (5' UTR), 14408 C > T (P4715L, RdRP gene), 3037 C > T (F942F, NSP3), 28881 G > A (R203K, N gene), 28882 G > A (R203R, N gene), 28883 G > C (G204R, N gene), and
Spike protein D614G and RdRp P323L: the SARS-CoV-2 mutations associated with severity of COVID-19.
Result: In the severely affected group, however, 241C>T, and 23403A>G coincided, and 3037C>T and 14408C>T occurred in subsets of them.
Result: In the spike prot
Discussion: Among numerous mutations observed in this study, two missense mutations, 14408C>T and 23403A>G, affecting RdRp and spike protein genes, respectively, were found most predominantly in the severely affected group compared with mildly affected group.
Discussion: The 23403A>G mutation in the genome of SARS-CoV-2 causes replacement of aspartic acid (D) with glycine (G) at position 614 (D614G) of the spike protein.
The Novel Coronavirus Enigma: Phylogeny and Analyses of Coevolving Mutations Among the SARS-CoV-2 Viruses Circulating in India.
PMID: 33496683
2020
JMIR bioinformatics and biotechnology
8Discussion: The ""major group"" of SARS-CoV-2 strains (66/95, 69.4%) represents the A2a clade reported previo
Discussion: Few strains from Europe and North America since February 2020 have shown the emergence of mutations like 3037C>T (F106F, NSP3), 23403A>G (D614G), and 28881-28883GGG>AAC (R203K and G204R, N) in the SARS-CoV-2 genome harboring the 14408C>T (P323L) mutation within the RdRP gene, suggesting a probable association or coexistence of 14408C>T (P323L) and the emerging higher number of novel point mutations compared to viral genomes from Asia.
SARS_CoV_2 mutation literature information.
PMID: 
2020
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