Method: The chosen sequences of single mutations included the following amino acid substitutions: L5F, L18F, D80A, S98F, A222V, A262S, P272L, K417 N, N439K, L452R, Y453F, S477 N, E484K, E484Q, N501T, N501Y, E583D, D614G, Q675H, Q675P, Q677H, PMID: 33875719
2021
Scientific reports
Introduction: In addition to D614G, NS3-Q57H, N-G204R and S-A222V mutations characterize the clades GH, GR and GV, respectively.
AutoVEM: An automated tool to real-time monitor epidemic trends and key mutations in SARS-CoV-2 evolution.
PMID: 33841748
2021
Computational and structural biotechnology journal
Discussion: Among the haplotypes of the 10 sites, H1-2 haplotype subgroup had 614D > G and 222A > V double mutation in S protein, which might be related to its rapid spread, should be further confirmed and verified.
Discussion: This lineage had 222A > V (C22227T) mutation on the basis of 614D > G (A23403G) mutation, which was consistent with the results of the present study.
Comparison of Clinical Features and Outcomes of Medically Attended COVID-19 and Influenza Patients in a Defined Population in the 2020 Respiratory Virus Season.
Introduction: In England, the VOC is currently replacing the recently dominant 20A.EU1 strain, characterized by A222V substitution in spike protein.
Discussion: The 20A.EU1 strain, a substrain of D614G that harbors A222V mutation in spike, emerged in Spain in early summer, 2020, spread over Europe, becoming the dominating strain (more than half of sequenced genomes) in several countries (Spain, England, Scotland, Wales, Ireland and Italy) in November, 2020, but was nearly absent outside of Europe.
Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677.
Discussion: For instance, the 20E (EU1) lineage characterized by an S: A222V polymorphism emerged suddenly in Europe over the summer, but has not been found to show any evidence for increased transmissibility and instead is thought to have been spread via holiday travel and relaxing summertime restrictions.
One Year of SARS-CoV-2: How Much Has the Virus Changed?
Abstract: As anticipated, our calculations capture previously reported mutations that arose in the first months of the pandemic, such as D614G (Spike), P323L (NSP12), and R203K/G204R (Nucleocapsid), but they also identify more recent mutations, such as A222V and L18F (Spike) and A220V (Nucleocapsid), among others.
Result: A222V and L18F in the Spike were also mutations detected in our analysis (MRs = 0.58 and 0.28 respectively) (Figure 1B).
Result: According to
World-wide tracking of major SARS-CoV-2 genome haplotypes in sequences of June 1 to November 15, 2020 and discovery of rapid expansion of a new haplotype.
Abstract: Spike D614G (and nsp12 L314P) mutations were most frequent (> 86%), whilst spike A222V/L18F have recently increased.
Method: Moreover, A222V appears to be increasing in Asia and Oceania from week 41, and S477N has increased to > 95% frequency across Oceania (N = 8321) with a peak of 9.3% in Europe (Additional file 1: Table S1, Additional file 1.
Method: Spike mutations A222V and L18F appear to have become entrenched in Europe reaching a total frequency of 70.6% and 31.6%, respectively (Additional file 1: Table S1, Additional file 1.
Method: Using the immuno-analytic
A Novel SARS-CoV-2 Viral Sequence Bioinformatic Pipeline Has Found Genetic Evidence That the Viral 3' Untranslated Region (UTR) Is Evolving and Generating Increased Viral Diversity.
Method: We conducted molecular dynamics simulations of variants A222V (N-terminal of SARS-CoV-2 residues 1-316), S477N (RBM domain, residues 331-530) and V11766F (stalk domain trimmer, residues 1,130-1,273).
Result: The A222V change is predicted to decrease the motility of the N-terminal of Spike protein (NTD), while the S477N and V1176F variants are predicted to increase the motility of the Receptor Binding Domain (RBD) and Stalk domain of the Spike protein, respectively (Figure 2E).
SARS_CoV_2 mutation literature information.
PMID: 
2021
Biochimie
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