SARS-CoV-2 genomic surveillance in Costa Rica: Evidence of a divergent population and an increased detection of a spike T1117I mutation.
PMID: 33905892
2021
Infection, genetics and evolution
Discussion: Genome sequences in this group have at least six variants, including the mutation A222V in the Spike protein and A220V in the nucleoprotein.
Discussion: None of the A222V in the Spike and the A220V in the nucleoprotein were found in our study.
A Comprehensive Molecular Epidemiological Analysis of SARS-CoV-2 Infection in Cyprus from April 2020 to January 2021: Evidence of a Highly Polyphyletic and Evolving Epidemic.
Abstract: Genetic analysis of whole SARS-CoV-2 genomic sequences of the aforementioned lineages revealed the presence of mutations within the S protein (L18F, DeltaH69/V70, S898F, DeltaY144, S162G, A222V, N439K, N501Y, A570D, D614G, P681H, S982A and D1118H) that confer higher transmissibility and/or antibody escape (immune evasion) upon the virus.
Introduction: Furthermore, mutations/deletions in the S-protein, such as L18F, DeltaH69/V70, PMID: 34188167
2021
Scientific reports
Introduction: According to additional mutation, the clade G can be split into three subclades, clade GH (Q57H variant of ORF3a), clade GR (RG203KR variant of the nucleocapsid protein), and GV (A222V variant of the spike protein).
The Spike of Concern-The Novel Variants of SARS-CoV-2.
Result: Secondly, the GV-GR variant defined by the presence of A222V in the S and G204R mutations in the N protein, along with the common D614G mutation of the G clade, were observed starting from August 2020 in Maharashtra (n = 1) and Telangana (n = 2).
Will Mutations in the Spike Protein of SARS-CoV-2 Lead to the Failure of COVID-19 Vaccines?
PMID: 33975397
2021
Journal of Korean medical science
Method: Among these mutations, five (L18F, S98F, A262S, A222V, and P272L) occurred in the N-terminal domain (NTD) of the S protein, and five (N439K, Y453F, S477N, E484K, and N501Y) appeared in the S protein RBD.
Method: There were 13 nonsynonymous mutations with a total frequency of > 1,000, and three mutations that are of interest, including D614G, A222V, L18F, S477N
D936Y and Other Mutations in the Fusion Core of the SARS-CoV-2 Spike Protein Heptad Repeat 1: Frequency, Geographical Distribution, and Structural Effect.
Result: In addition, the GH clade presents the NS3-Q57H mutation, the GR clade presents the N-G204R mutations, and GV clade presents the S-A222V mutation.
Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern.
Introduction: Therefore, the clade GH is defined by Q57H mutation in NS3, the clade GR is defined by G204R mutation in N-protein; and the clade GV is defined by A222V mutation in S-protein.
Genetic Diversity of SARS-CoV-2 over a One-Year Period of the COVID-19 Pandemic: A Global Perspective.
Result: (ii) During the pandemic, from July to December 2020, the prevalence of A222V in spike, A220V in nucleocapsid (Figure 5C), and V30L in ORF10 increased continuously in Europe and Africa, while their emergence in other continents was less common.
Result: Fifteen variants with the prevalence >5% were identified, including (i) four variants in nucleocapsid: S194L (6.29%), R203K (28.45%), G204R (28.13%), and A220V (25.96%); (ii) four variants in spike: L18F (12.08%), A222V (26.14%), S477N (6.62%), and
Impact of meteorological parameters and population density on variants of SARS-CoV-2 and outcome of COVID-19 pandemic in Japan.
Result: However, during the second wave starting from October 2020 substitution point mutations E780Q, K417N, T478I, N501Y, E484K, N439K, V1176F, S477N and A222V became common at spike protein in the isolates in Japan.
Result: Point mutation at RBDs namely, Y145del had strong correlation with maximum temperature (rs = 0.61), snow fall (rs = 0.41), N501Y with maximum temperature (rs = 0.46) and sun hours (rs = 0.49), N439K with minimum temper
SARS_CoV_2 mutation literature information.
PMID: 
2021
Infection, genetics and evolution
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