Abstract: Among the 15 single-nucleotide polymorphisms (SNP
Table: A222V
Discussion: A222V is also predicted to be located within one of the epitopes recognized by unexposed humans.
Discussion: Although the spike A222V mutation (within the NTD) has not yet been reported to recurrently emerge during long-term infections, it has been specially focused by the scientific community.
Discussion: Altogether, our results consolidate the expectation that A222V might have a still to be disclosed functional impact on spike host-interacting activities.
Discussion: In addition, another spike A222V-bearing variant was the cause of one of the first reinfection cases reported worldwide.
Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.
Discussion: Other common mutations in the spike (S) protein, including A222V (C22227T), L81S (C21614T), and S477N (G22992A), are co-occurred with D614G in 100,401 sequences (21.8%), 45,943 sequences (10%) and 23,426 sequences (5.1%), respectively (Covid19 CG data: https://covidcg.org/?tab=group).
Ongoing global and regional adaptive evolution of SARS-CoV-2.
Introduction: The variants A222V (clade 20A.EU1) and S477N (clade 20A.EU2) emerged in the summer of 2020 in Spain and have rapidly shown diffusion within Europe.
Evolutionary Tracking of SARS-CoV-2 Genetic Variants Highlights an Intricate Balance of Stabilizing and Destabilizing Mutations.
Abstract: We recorded persistence of D614G, S477N, A222V, and V1176F variants and a global expansion of the PANGOLIN variant B.1.
Result: Structural analysis of double (D614G + S477N; D614G + A222V) and triple (D614G + S477N + A222V) mutation patterns in the S protein indicated DeltaDeltaG values of 0.228, 0.195 and 0.129, respectively (Table 3).
Table: A222V
Discussion: Our analysis confirmed previously recorded positive natural selection of the D614G, S
Updated SARS-CoV-2 single nucleotide variants and mortality association.
Figure: (A) S:A222V, (B) S:L18F, (C) ORF10:V30F, (D) N:A220V, (E) nsp7:L71F, (F) nsp14:A320V, (G) S:V1176F, (H) Ratios of nonsynonymous SNVs in the whole region or IDR of proteins, S, ORF1ab, and ORF3a, (I) Hydrophobic scores before (REF) and after alternations (ALT) of nonsynonymous SNVs in the IDRs of proteins, S, ORF1ab, and ORF3a.
Discussion: For e
The Antigenicity of Epidemic SARS-CoV-2 Variants in the United Kingdom.
Discussion: D614G+L18F+A222V and D614G+A222V were the main epidemic variants before the emergence of VOC-202012/01.
Discussion: L18F and A222V are typical mutations of the B.1.177 lineage.
Discussion: Both the D614G+L18F+A222V and D614G+A222V variants showed increased sensitivity to convalescent sera and sera elicited by inactivated-virus vaccines, which may be caused by the A222V mutation.
Discussion: This study showed that A222V was more sensitive to most mAbs, whereas
Design of a companion bioinformatic tool to detect the emergence and geographical distribution of SARS-CoV-2 Spike protein genetic variants.
PMID: 33380328
2020
Journal of translational medicine
Result: Next, there are a few variants with a frequency of 2-7% that are slowly rising in the viral populations, namely S477N, Q613H and A222V.
SARS_CoV_2 mutation literature information.
PMID: 
2021
mSphere
Browser Board
Co-occurred Entities
Filtrator
ViMRT