Method: Delta AY.1 variant had D614G, E156G, F157del, K417N, L452R, P681R, R158del, T19R, T95I and T478K substitutions; the Delta variant had A222V, D614G, D950N, G142D, L452R, P681R, T19R, T478K substitutions; and the B.1 variant had the D614G substitution in the spike protein.
Neutralisation Hierarchy of SARS-CoV-2 Variants of Concern Using Standardised, Quantitative Neutralisation Assays Reveals a Correlation With Disease Severity; Towards Deciphering Protective Antibody Thresholds.
Abstract: The AY.4.2 spike displays three additional mutations (T95I, Y145H and A222V) in the N-terminal domain when compared to the original Delta variant (B.1.617.2) and remains poorly characterized.
Introduction: The A222V mutation was noted in the B.1.177 (or 20A.EU1) lineage that emerged in Spain and spread throughout Europe in summer 2020.
Introduction: The AY.4.2 sub-lineage is notably defined by the presence of Y145H and A222V mutations that lie within the N-terminal Domain (NTD) of the spike.
Introduction: The effect of combined Y145H and A222V mutat
Genomic epidemiological analysis of SARS-CoV-2 household transmission.
Discussion: These include D614G, associated with the B.1 lineage observed in this family cluster, which is now ubiquitous and appears to have a moderate effect on SARS-CoV-2 transmissibility; A222V, present in the 20A.EU1 (B.1.177) cluster which has spread quickly across Europe from Spain and become dominant in Irish sequences; and N439K, a variant for which there is evidence to suggest increased ACE2 receptor binding affinity and immune-escape from neutralising antibodies.
Genomic surveillance reveals the detection of SARS-CoV-2 delta, beta, and gamma VOCs during the third wave in Pakistan.
Discussion: For example, R6997P (ORF1Ab), A222V (S), A220V (N), and V30L (ORF10) co-occurred in 0.5% of all cases in July 2020 and exceeded 50% of all cases by January 2021 worldwide.
Analysis of 329,942 SARS-CoV-2 records retrieved from GISAID database.
PMID: 34735950
2021
Computers in biology and medicine
Discussion: In S, it was C22227T (A222V) with 22.25%.
Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases.
PMID: 34760721
2021
Frontiers in cellular and infection microbiology
Introduction: Further, L clade evolved to V (G11083T, G26144T, NSP6-L37F + NS3-G251V) and G (C241T, C3037T, A23403G, and S-D614G); and later G clade evolved into GH (C241T, C3037T, A23403G, G25563T includes S-D614G + NS3-Q57H), GR (C241T, C3037T,
Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach.
Result: Overall, A222V had the highest ratio of nonsynonymous and synonymous site (dN/dS ratio) substitutions (FUBAR [fast, unconstrained Bayesian approximation] test, omega=37.06), with a GCT (A) to GTT (V) change at the second codon position commonly observed in B.1.177, followed by residues 5 (omega=28.91), 477 (omega=28.22), and 98 (omega=28.05).
SARS_CoV_2 mutation literature information.
PMID: 
2022
Science immunology
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