literature

SARS_CoV_2 mutation literature information.

Phylogenomics reveals viral sources, transmission, and potential superinfection in early-stage COVID-19 patients in Ontario, Canada.

PMID: 33580132 2021 Scientific reports

Discussion: The presence of three additional polymorphic sites at C17747T, A17858G, and C18060T exclusively present in North America provide support for the USA origin hypothesis described by our phylogenetic analysis.

Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants.

PMID: 33589648 2021 Communications biology

Introduction: Additionally, three concurrent missense mutations 17747C>T-(P504L), 17858A>G-(Y541C), and 28144T>C-(L84S) tend to fade out, while the other eight concurrent mutations may enhance the infectivity of SARS-CoV-2.

Result: One possible reason for the declined ratios for 17858A>G-(Y541C) and 17747C>T-(P504L) may be due to the efficient lockdown measures enforced in WA and CA at the early stage of the outbreak in the US.

Result: Three of the top 11 missense mutations, i.e., 17858A>G-(Y541C<

Molecular epidemiology analysis of early variants of SARS-CoV-2 reveals the potential impact of mutations P504L and Y541C (NSP13) in the clinical COVID-19 outcomes.

PMID: 33798758 2021 Infection, genetics and evolution

Result: Variation heatmap of countries demonstrated the composition of several significant genetic variation sites, including variation in ORF1ab (8782C- > T, NSP4:S76S, synonymous), S (23403 A- > G, S:D614G, missense), ORF1ab (17858 A- > G, NSP13:Y541C, missense), and ORF1ab (17747C- > T, NSP13:P504L, missense).

AutoVEM2: A flexible automated tool to analyze candidate key mutations and epidemic trends for virus.

PMID: 34512928 2021 Computational and structural biotechnology journal

Method: In our study in the early stage of the pandemic (2019.12 - 2020.05.05), we found 9 specific mutation sites (C241T, C3037T, C8782T, C14408T, C17747T, A17858G, C18060T, A23403G, and T28144C) of SARS-CoV-2.

Identification and characterization of SARS-CoV-2 clusters in the EU/EEA in the first pandemic wave: additional elements to trace the route of the virus.

PMID: 34637920 2021 Infection, genetics and evolution

Result: SS1 genomes from Iceland showed a different profile carrying mainly the C17747T, A17858G, T17531C, C18060T and A24694T mutations.

Geographic and Genomic Distribution of SARS-CoV-2 Mutations.

PMID: 32793182 2020 Frontiers in microbiology

Table: A17858G

Characterizing SARS-CoV-2 mutations in the United States.

PMID: 32818213 2020 Research square

Introduction: Among them, mutations 17858A>G-(Y541C), 17747C>T-(P504L), and 27964C>T-(S24L) were originated and prevalent mainly in the US, attributing to the unique characteristics of COVID-19 in the US.

Result: The other three mutations, 17747C>T-(P504L), 17858A>G-(Y541C), and

Result: The third pair of mutations, 17747C>T-(P504L) and 17858A>G-(Y541C), first detected and occurred mostly in the US, have an identical evolution trajectory.

Genetic grouping of SARS-CoV-2 coronavirus sequences using informative subtype markers for pandemic spread visualization.

PMID: 32941419 2020 PLoS computational biology

Result: WA1 lineage is noted to have three characteristic SNVs, namely, C17747T, A17858G, and C18060T which correspond matches with our ISM positions of 10, 11 and 12 respectively.

Evaluation of the potency of FDA-approved drugs on wild type and mutant SARS-CoV-2 helicase (Nsp13).

PMID: 32980406 2020 International journal of biological macromolecules

Abstract: Incidence of C17747T and A17858G mutations were observed to be much higher than others and they were on Nsp13, a vital enzyme of SARS-CoV-2.

Result: According to the genome sequence data by 7 April 2020; there is no isolate harboring C17747T and A17858G mutations simultaneously in Asia, Africa and continental Europe yet (Supplement.

Result: Accordingly, we have selected two mutations C17747T and A17858G on the gene sequences encoding helicase being present simultaneously in 11,6% of 3458 isolates (Supplement.

Characterization of local SARS-CoV-2 isolates and pathogenicity in IFNAR(-/-) mice.

PMID: 33015402 2020 Heliyon

Table: A17858G

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