Result: We found that 30% of the mild/severe cases had the A105V mutation in the ORF7a region and 8.9% presented a T987N mutation in NSP3 domain, ORF1ab region.
Table: p.Ala105Val
Discussion: Another non-synonymous recurrent mutation in a large number of our samples was A105V in ORF7a.
Discussion: As such, a more stable ORF7, due to a A105V mutation, may reduce immune response and, consequently, more severe COVID symptoms.
Discussion: As such, patients infected with A105V had higher values of CRP, compared with non- PMID: 34943191
2021
Biology
5Result: This was reflected in the ""A105V vs."
5Result: WT"" analysis (Figure 4A, blue line), but also when comparing A105V to A106V simulations (Figure 4A, red line)."
Conclusion: Analysis of the clinical and genomic data revealed a strong link between disease severity and mortality and a particular mutation in the ORF7a protein, A105V.
Conclusion: Structural computational analyses showed that A105V changed the conformational landscape most likely by altering the binding affinity of ORF7a protein.
Conclusion: The study demonstrates the importance of ORF7a mutation A105V as a gain-of-function protein and paves the way for further work in det
SARS_CoV_2 mutation literature information.
PMID: 
2021
Frontiers in microbiology
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