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 SARS_CoV_2 mutation literature information.


  A novel pseudovirus-based mouse model of SARS-CoV-2 infection to test COVID-19 interventions.
 PMID: 33926459       2021       Journal of biomedical science
Result: 293TT cells expressing hACE2 were pretreated with RBD protein one hour prior to WT, 19del, or 19del + D614G PsV infection.
Figure: Quantification of bioluminescence signal of mice infected with 19del (
Figure: Representative bioluminescence and kinetics of mouse infection with 19del or 19del + D614G pseudoviruses (c).


  In vivo characterization of emerging SARS-CoV-2 variant infectivity and human antibody escape potential.
 PMID: 34648735       2021       Cell reports
Method: 24-hours later, normalized amounts of WT (no 19del), WT, D614G, N501Y (no 19del), N501Y, N501Y + D614G, N501Y + L452R + D614G, or N501Y + K417N + Method: To generate 19del + D614G mutation PsV plasmid (pCMV3-SARS-CoV-2-S-cd19-D614G), site-directed mutagenesis was used for generating D614G mutation in the SARS-CoV-2 spike sequence.



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