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 IV mutation literature information.


  Rapid quantification of single-nucleotide mutations in mixed influenza A viral populations using allele-specific mixture analysis.
 PMID: 19761797       2010       Journal of virological methods
Abstract: The FluASMA assays target L26F, V27A, A30T, and S31N mutations in the A/Albany/1/98 (H3N2) M2 gene and H275Y mutation in the A/New Caledonia/20/99 (H1N1) NA gene and have a limit of quantification of 0.25-0.50% mutant.


  Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus.
 PMID: 19905033       2009       Biochemistry
Abstract: A lead compound emerging from these investigations, spiro[5.5]undecan-3-amine, is an effective inhibitor of wild-type A/M2 channels and L26F and V27A mutant ion channels in vitro and also inhibits replication of recombinant mutant viruses bearing these mutations in plaque reduction assays.
Abstract: The A/M2 proton channel of influenza A virus is a target for the anti-influenza drugs amantadine and rimantadine, whose effectiveness was diminished by the appearance of naturally occurring point mutants in the A/M2 channel pore, among which the most common are S31N, V27A, and L26F.
Introduction: Although the S31N mutation was observed in more then 90% of influenza A ca


  Detection of adamantane-resistant influenza on a microarray.
 PMID: 18299250       2008       Journal of clinical virology
Abstract: Microarray data from a larger set of samples were further analyzed using an artificial neural network and resulted in a correct identification rate of 94% for influenza virus samples that had V27A and S31N mutations.
Abstract: STUDY DESIGN: We have taken advantage of functional genomics and microarray technology to design a DNA microarray that can detect the two most common mutations in the M2 protein associated with adamantane resistance, V27A and S31N.


  Combination chemotherapy, a potential strategy for reducing the emergence of drug-resistant influenza A variants.
 PMID: 16516984       2006       Antiviral research
Abstract: After five sequential passages in MDCK cells, the M2 protein of viruses cultivated with amantadine alone mutated at positions V27A and S31N/I.



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