Result: We observed that WT NS1 of H7N9 significantly inhibited IAV-induced RIG-I expression, but S212P amino acid substitution impaired its ability to inhibit the RIG-I expression (Figures 3A, B and Additional file 3).
Figure: 293T cells transfected with plasmids expressing H7N9 NS1-WT (WT), NS1-S212P (S212P) or EV were infected with WSN (C) or PR8 delNS1 virus (D) as described in (A, B), then cells were harvested and cell extracts were prepared for Western blotting using indicated antibodies.
Figure: A 293T cells transfected with plasm
Figure: H7N9 NS1 S212P mutation causes a decrease of its ability to suppress RIG-I expression and STAT1 activation.
IV mutation literature information.
PMID: 
2018
Veterinary research
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