Method: The H7N9 NS1 mutants, NS1 (R55E), NS1 (H63Q), NS1 (E70K), NS1 (P87S), NS1 (S114P), NS1 (A143T), NS1 (I178V) and NS1 (S212P) were generated by site-directed mutagenesis with the QuickChange XL system (Stratagene, La Jolla, CA, USA).
Result: The substitutions were the following (avian_residue/Position/human_residue): R55E,
Identification of Amino Acid Residues Responsible for Inhibition of Host Gene Expression by Influenza A H9N2 NS1 Targeting of CPSF30.
Result: Altogether, these results indicate that the combination of amino acid residues F103L/M106I/S114P/D125G/D139N in WI/66 NS1 protein is sufficient to loss its ability to inhibit host gene expression.
Result: In order to evaluate the ability of HK/97and WI/66 NS1 proteins and their respective HK 13 (L103F/I106M/P114S/G125D/N139D) and WI 13 (F103L/M106I/S114P/D125G/D139N) mutants to counter
IV mutation literature information.
PMID: 
2018
Veterinary research
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