Abstract: Moreover, we found that R294K substitution results in reduced NA catalytic efficiency along with lower viral fitness.
Result: In the case of zanamivir, laninamivir and peramivir, the R294K mutation conferred less resistance relative to oseltamivir carboxylate (Table 1).
Result: The R294K substitution impairs H7N9 virus fitness and N9 enzymatic activity.
Result: The R294K substitution in N9 from epidemic H7N9 confers multidrug resistance.
Result: To gain insight into the structural basis of the N9-R294K drug-resistant substitution, high-resolution crystal structures of Anhui N9 and Shanghai
IV mutation literature information.
PMID: 
2013
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