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 IV mutation literature information.


  Study of oseltamivir and zanamivir resistance-related mutations in influenza viruses isolated from wild mallards in Sweden.
 PMID: 24558492       2014       PloS one
Method: The literature describing NAI resistance mutations has been reviewed, whereupon nine OC (V116A, I117V, E119V, D198N, I222V, H274Y, R292K, N294S and I314V) and ten ZA (V116A, R118K, E119G/A/D, Q136K, D151E/G/N, R152K, R224K, E276D, R292K and R371K)


  Host immunological response and factors associated with clinical outcome in patients with the novel influenza A H7N9 infection.
 PMID: 24350809       2014       Clinical microbiology and infection
Abstract: Genetic characterization of the H7N9 virus revealed an Arg292Lys mutation in the neuraminidase gene associated with oseltamivir-resistance.


  Emergence of a novel drug resistant H7N9 influenza virus: evidence based clinical potential of a natural IFN-alpha for infection control and treatment.
 PMID: 24350808       2014       Expert review of anti-infective therapy
Abstract: The emerging H7N9 viruses are resistant to the M2-ion channel blockers because of a S31N mutation in the M2 protein; additionally, some H7N9 isolates have gained neuraminidase R292K substitution resulting in broad resistance to neuraminidase inhibitors.


  Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza a virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution.
 PMID: 23794010       2014       Cell biochemistry and biophysics
Abstract: In particular, influenza strains with a R292K NA mutation are highly resistant to the oseltamivir.


  Simultaneous detection of oseltamivir- and amantadine-resistant influenza by oligonucleotide microarray visualization.
 PMID: 23451169       2013       PloS one
Discussion: For instance, I117V, I117M, S247N, I223R, N294S, and R292K of NA have been reported to be associated with NA inhibitor resistance, and some of them had combinatorial, compensatory, or synergistic effects.


  Molecular assays for quantitative and qualitative detection of influenza virus and oseltamivir resistance mutations.
 PMID: 23597879       2013       The Journal of molecular diagnostics
Abstract: Four assays are included for detection of oseltamivir resistance mutations H275Y in prepandemic and pandemic influenza A/H1N1 and E119V and R292K in influenza A/H3N2 neuraminidase.


  Occurrence and characterization of oseltamivir-resistant influenza virus in children between 2007-2008 and 2008-2009 seasons.
 PMID: 23646055       2013       Korean journal of pediatrics
Method: For the genotypic analysis, mutations of amino acid regions related to drug resistance (E119V, R152K, H274Y, R292K, and N294S) were examined, via sequence analysis of NA gene.
Result: NA gene analysis was conducted on influenza viruses isolated from 51 patients (group A, 29 patients; group B, 22 patients) during the first study period in order to examine the drug resistance-related mutation of NA inhibitor (E119V, R152K, H274Y, R292K, N294S).


  Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza a virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution.
 PMID: 23951116       2013       PloS one
Method: All R292K mutants showed relatively low NA activity and were diluted 1:2 while wild type virus samples were further diluted.
Method: Sequencing of the HA gene was performed on 8 selected samples, among which 6 were evaluable, from the 12 microg/L experiment that were NA sequenced as wild type, R292K, R292K and D113N, R292K and D141N prior to and after egg propagation.
Result: At 12 microg/L of OC, the resistance mutation R292K (the arginine codon AGA changed to the lysine codon AAA) in the NA occurred in the first generation of mallards 4 days pi as a mixed genotype, and dominated from day


  Generation and Characterization of Recombinant Influenza A(H1N1) Viruses Resistant to Neuraminidase Inhibitors.
 PMID: 24524021       2013       Osong public health and research perspectives
Introduction: Other NA mutations (N2 numbering: E119G, H274Y, R292K, and N295S) that have been reported to confer resistance to NAIs were each introduced into recombinant A/Vietnam/1203/04(H5N1) influenza virus.


  Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza a virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution.
 PMID: 23860768       2013       mBio
Abstract: Our results confirmed that the NA R292K mutation confers resistance to oseltamivir, peramivir, and zanamivir in the novel human H7N9 viruses.
Abstract: Resistance to NA inhibitors conferred by the R292K mutation in a human influenza virus H7N9 isolate can be masked by a mixed R/K viral population, and this should be taken into consideration while monitoring antiviral resistance in patients with H7N9 infection.
Introduction: Recently, the emergence of the R292K mutation in 2 of 14 patients infected with the novel H7N9 influenza virus was reported to be associated with poor clinical outcome.



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