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 IV mutation literature information.


  Aurintricarboxylic acid inhibits influenza virus neuraminidase.
 PMID: 19014974       2009       Antiviral research
Result: An in vitro selection study demonstrated that the mutation R292K is the most common substitution in Group 2 NAs resistant to oseltamivir.


  Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza a virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution.
 PMID: 26621436       2008       Journal of chemical theory and computation
Abstract: Notably, in every case, the simulation results correctly predict that loss of binding occurs as a result of the R292K mutation.
Abstract: Per-residue binding footprints reveal that changes in DeltaDeltaEcoul for R292K-wildtype at position 292 parallel the change in experimental fold resistance energies (DeltaDeltaGR292K-WT) with S03 < S00 < S02 < S01.
Abstract: The goal is to elucidate which structural and energetic properties change as a result of a mutation at position R292K.


  Neuraminidase inhibitor-resistant recombinant A/Vietnam/1203/04 (H5N1) influenza viruses retain their replication efficiency and pathogenicity in vitro and in vivo.
 PMID: 17855542       2007       Journal of virology
Abstract: Four NA mutations (E119G, H274Y, R292K, and N294S) that have been reported to confer resistance to NA inhibitors were each introduced into recombinant A/Vietnam/1203/04 (VN1203) H5N1 influenza virus.
Abstract: The E119G and R292K mutations significantly compromised viral growth in vitro, but the H274Y and N294S mutations were stably maintained in VN1203 and PR8 viruses.


  H5N1 Oseltamivir-resistance detection by real-time PCR using two high sensitivity labeled TaqMan probes.
 PMID: 17055070       2007       Journal of virological methods
Introduction: Eighteen percent of the children (N = 9/50) had neuraminidase mutations at Arg292Lys (N = 6/9) or Glu119Val (N = 2/9) or Asn294Ser (N = 1/9).


  Mutations conferring zanamivir resistance in human influenza virus N2 neuraminidases compromise virus fitness and are not stably maintained in vitro.
 PMID: 16891631       2006       The Journal of antimicrobial chemotherapy
Abstract: RESULTS: H3N2 viruses generated by reverse genetics with H274Y, R292K E119V and E119D mutations were rescued.


  Comparative activities of oseltamivir and A-322278 in immunocompetent and immunocompromised murine models of influenza virus infection.
 PMID: 16479509       2006       The Journal of infectious diseases
Abstract: A substitution in the neuraminidase (NA) active site (Arg292Lys) was detected in the cloned virus recovered from an oseltamivir-treated mouse.


  Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibility.
 PMID: 16189083       2005       Antimicrobial agents and chemotherapy
Abstract: Both mutants showed decreased sensitivity to oseltamivir carboxylate, and the RG R292K-NA virus showed cross-resistance to zanamivir.
Abstract: The NA defect caused by the R292K mutation was associated with compromised growth and transmissibility, whereas the growth and transmissibility of the RG E119V-NA virus were comparable to those of RG WT virus.
Abstract: The R292K mutation caused greater reduction of sialidase activity and thermostability than the E119V mutation.


  Resistant influenza A viruses in children treated with oseltamivir: descriptive study.
 PMID: 15337401       2004       Lancet (London, England)
Abstract: FINDINGS: We found neuraminidase mutations in viruses from nine patients (18%), six of whom had mutations at position 292 (Arg292Lys) and two at position 119 (Glu119Val), which are known to confer resistance to neuraminidase inhibitors.
Abstract: Sensitivity testing to oseltamivir carboxylate revealed that the neuraminidases of viruses that have an Arg292Lys, Glu119Val, or Asn294Ser mutation were about 10(4)-10(5)-fold, 500-fold, or 300-fold more resistant than their pretreatment neuraminidases, respectively.


  Neuraminidase sequence analysis and susceptibilities of influenza virus clinical isolates to zanamivir and oseltamivir.
 PMID: 12821478       2003       Antimicrobial agents and chemotherapy
Abstract: The drug susceptibilities of known zanamivir- and oseltamivir-resistant viruses with the NA mutations E119V, R292K, H274Y, and R152K fell well outside the 95% confidence limits of the IC(50)s for all natural isolates.


  Evaluation of neuraminidase enzyme assays using different substrates to measure susceptibility of influenza virus clinical isolates to neuraminidase inhibitors: report of the neuraminidase inhibitor susceptibility network.
 PMID: 12574276       2003       Journal of clinical microbiology
Abstract: We evaluated three NA inhibition assays against a panel of five clinical isolates each of influenza virus A/H1N1, A/H3N2, and B strains and four viruses with a defined resistance genotype (R292K, H274Y, R152K, and E119V).



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