literature

IV mutation literature information.

Dynamic Variation and Reversion in the Signature Amino Acids of H7N9 Virus During Human Infection.

PMID: 29688498 2018 The Journal of infectious diseases

Abstract: Neuraminidase (NA) R292K, basic polymerase 2 (PB2) E627K, and D701N were the 3 most dynamic mutations.

Abstract: The oseltamivir resistance-related NA R292K mutation was present in 9 samples from 5 patients, including 1 sample obtained before antiviral therapy.

Discussion: A previous study indicated that the introduction of the R292K mutation into the NA segment leads to competitive fitness loss by avian H7N9 influenza virus.

Discussion: A previous study showed that NA R292K emerged under antiviral pressure conferred by

PMID: 30024940 2018 PloS one

Result: However, where viruses with the R292K substitution in NA generally increased in prevalence throughout the course of the experiment, to become dominant at the latest time points, none of the additional substitutions followed a similar trend.

Result: Illumina NGS revealed numerous mutations in HA and NA of the viruses beyond R292K, present in all Oseltamivir treated animals (Table 1, S1 Table).

Result: Illumina NGS was conducted to analyze the emergence of mutations beyond R292K that were potentially associated with Oseltamivir treatment in the HA and NA genes of influenza viruses in immunocompetent and immunocompromised ferrets at 2, 4, 6, 8 and 10 dpi.

Identification of two residues within the NS1 of H7N9 influenza A virus that critically affect the protein stability and function.

PMID: 30285871 2018 Veterinary research

Discussion: For example, G219S and K58I combined mutations or three-amino-acid mutations (V186G/K-K193T-G228S or V186N-N224K-G228S) in H7N9 HA protein resulted in high affinity to alpha-2,6-linked sialic acid (SA) and increased HA stability, and a R292K mutation in H7N9 NA protein facilitated drug resistance through decreasing the binding interaction with oseltamivir, the most commonly used anti-influenza drug.

Susceptibility of Influenza Viruses to the Novel Cap-Dependent Endonuclease Inhibitor Baloxavir Marboxil.

PMID: 30574137 2018 Frontiers in microbiology

Result: The influenza A(H1N1)pdm09-NA/H275Y, A(H3N2)-NA/E119V or -NA/R292K, and influenza B-NA/D197E mutant viruses exhibited HRI or RI against at least one of the four NA inhibitors, whereas no significant differences in baloxavir susceptibilities were found between the NA inhibitor-resistant and wild-type viruses by using either assay (Table 2); however, influenza B viruses showed higher IC50 values than influenza A viruses, as previously reported.

Table: R292K

Prospective surveillance of antiviral resistance in hospitalized infants less than 12 months of age with A(H3N2) influenza infection and treated with oseltamivir.

PMID: 28205506 2017 Antiviral therapy

Abstract: Sanger sequencing revealed the selection of the NA-R292K substitution in both instances (after dose number 10 on day 6).

Evolution of the neuraminidase gene of seasonal influenza A and B viruses in Thailand between 2010 and 2015.

PMID: 28410396 2017 PloS one

Method: We analyzed for the presence of NA substitutions associated with either NAI-resistant genotype in different NA subtypes (E119V/I/A/G, H274Y, R292K, and N294S: N2 numbering) or reduced susceptibility genotype to NAIs (Q136K, D151E/V/D, D198N/G/E/Y, I222V/T/K/R/M, S246N, E276D, and R371K: N2 numbering) among influenza A and B viruses.

Discussion: Drug resistance characterized by

Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2015-2016.

PMID: 28802866 2017 Antiviral research

Method: E119V is known to confer HRI by oseltamivir, while R292K confers HRI by oseltamivir/peramivir and RI by zanamivir/laninamivir.

Method: Three sequences of A(H3N2) viruses displaying NI contained the following AASs: E119V/E, R292K/R and Q136K/Q (Table S3).

Phylogenetic and genetic characterization of a 2017 clinical isolate of H7N9 virus in Guangzhou, China during the fifth epidemic wave.

PMID: 29019145 2017 Science China. Life sciences

Abstract: The 2017 isolate also possesses an R292K substitution in the neuraminidase (NA) protein, which confers oseltamivir resistance.

Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains.

PMID: 28951584 2017 Scientific reports

Result: It should be noted that these three new 150-cavity inhibitors were not located within the V4 anchor, which contains residues I222 and H274, suggesting that these inhibitors may not be affected by the two drug-resistant mutations R292K, N294S and H274Y.

Result: This includes the mutations R292K (E1 and V2) and E119V (H1) to name a few.

Discussion: Mutations of residues in various anchor regions of NA, including E199V, D151E, H274Y, R292K, and N294S strains, may alter their characteristics and interaction modes, disrupting drug binding.

Persistent Infection of Drug-resistant Influenza A Virus during Chemotherapy for Malignant Lymphoma.

PMID: 27374689 2016 Internal medicine (Tokyo, Japan)

Abstract: Virological analyses revealed that he was infected with the NA inhibitor-resistant A (H3N2) virus possessing an R292K substitution in the NA protein.

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