literature

IV mutation literature information.

Molecular Characterization of Seasonal Influenza A and B from Hospitalized Patients in Thailand in 2018-2019.

PMID: 34070388 2021 Viruses

Discussion: For H3N2 viruses, we did not detect the mutations conferring resistance to neuraminidase inhibitors such as E119V, D151E, I222V, R224K, E276D, N249S, R292K, and R371K in the NA gene segment of our H3N2 isolates.

An influenza A(H5N8) virus isolated during an outbreak at a poultry farm in Russia in 2017 has an N294S substitution in the neuraminidase and shows reduced susceptibility to oseltamivir.

PMID: 33933515 2021 Antiviral research

Abstract: Fewer than 1% of analyzed viruses had amino acid substitutions associated with reduced susceptibility to baloxavir (PA-E199G, PA-E199E/G) or reduced or highly reduced inhibition by neuraminidase inhibitors (NA-R150/152K, NA-I221/222M, NA-I221/222I/M, NA-I221/222V, NA-I115/117V, NA-G145/147R, NA-

PMID: 33713731 2021 Antiviral research

Abstract: All cultured viruses with the known resistance substitutions H275Y or R292K showed reduced susceptibility to oseltamivir in the NA-star assay.

Abstract: Known resistance substitutions were detected by mutation specific RT-PCR in viruses of 57 of 1803 (3.2%) oseltamivir-treated individuals, including 39 individuals infected with A/H1N1pdm09 [H275Y] virus and 18 with A/H3N2 [R292K] virus.

Susceptibility of widely diverse influenza a viruses to PB2 polymerase inhibitor pimodivir.

PMID: 33581212 2021 Antiviral research

Result: Their replication was inhibited by pimodivir at low nanomolar concentrations, 2.77-28.59 nM (Table 4), except one NA inhibitor-resistant virus, A/turkey/Minnesota/833/80 (H4N2) carrying NA-R292K mutation (ty/MN/80-NA-R292K), which displayed highly elevated average pimodivir IC50, 644.17 nM.

Identification and Characterization of Novel Antibody Epitopes on the N2 Neuraminidase.

PMID: 33568453 2021 mSphere

Introduction: The mutations E119V, R292K, and N294S have been shown to confer oseltamivir resistance in N2 containing viruses.

Enhanced Potency of a Broad H7N9-Neutralizing Antibody HNIgGA6 Through Structure-Based Design.

PMID: 32636820 2020 Frontiers in microbiology

Introduction: Neuraminidase inhibitor (NAI) resistance (R292K substitution in NA) was detected in both NA inhibitor-treated patients and a few nonhuman-derived HP-H7N9 strains.

Reassortment and adaptive mutations of an emerging avian influenza virus H7N4 subtype in China.

PMID: 31951605 2020 PloS one

Result: Strikingly, no H274Y or R292K in NA changes, which had been associated with oseltamivir resistance, were identified in any of the H7N4 isolates, and not in A/Anhui/1/2013 or partly in A/Shanghai/1/2013, which explained the patient's positive response to oseltamivir treatment and full recovery.

Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza a virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution.

PMID: 32631240 2020 BMC infectious diseases

Conclusion: We examined the HD15-influenza-positive sample by polymerase chain reaction and sequence analysis, which detected a dual E119D/R292K mutant influenza A/H3N2.

Figure: Clinical course in a severely immunosuppressed patient with peramivir-resistant dual E119D/R292K neuraminidase mutated-influenza A/H3N2 after allo-HCT allo-HCT, allogeneic hematopoietic cell transplantation; A-VVV, cytosine arabinoside, etoposide, vincristine, and vinblastine; CsA, cyclosporine A; HU, hydroxyurea; Lym, lymphocyte; PSL, prednisolone.

Discussion: The patient developed seasonal influenza A/H3N2 infection while in a highly immunocompromised state post-transplant-relapsed leukemia; treatment with 1-day oseltamivi

Characterization of neuraminidase inhibitor-resistant influenza virus isolates from immunocompromised patients in the Republic of Korea.

PMID: 32631440 2020 Virology journal

Introduction: The typical drug-resistance substitutions in NA include H275Y, E119D/G, and Q136R for A(H1N1)pdm09; E119V, D151G/V/D, R224K, E276D, R292K, and N294S for A (H3N2); and G104E, E117A/D, H134Y, and R150K for B virus, although additional single and combination mutations may also result in NAI drug resistance (World Health Organization (WHO)).

Functional neuraminidase inhibitor resistance motifs in avian influenza A(H5Nx) viruses.

PMID: 32750468 2020 Antiviral research

Introduction: In this study we introduced four NAI resistance-associated mutations (E119V, H274Y, R292K, N294S) into three recent H5Nx viruses containing different avian NA subtypes: N2, N6 and N8.

Introduction: There are known motifs that confer reduced susceptibility to the NAI drugs: E119V, H274Y, R292K and N294S (amino acid numbering refers to the N2 subtype), amongst others but the level of reduced susceptibility and which drug they affect are not universal amongst the influenza A virus NAs or even NA subtype.

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