Figure: Conceptual model of the generalized inferred evolutionary pathways and virulence outcomes of NP-Q357K in influenza A viruses.
Discussion: Therefore, because EA H1N1 SIVs have acquired the trait necessary to cause a human influenza pandemic, EA SIVs with NP-Q357K pose a greater risk
Discussion: Therefore, the NP-Q357K substitution was already present when the avian influenza viruses circulated in pigs, allowing the viruses to infect humans.
Discussion: Thus, the NP-Q357K mutation in the EA SIVs is fully responsible for the enhanced pathogenicity phenotype, and enhanced the polymerase activity, replication, and infectivity of the viruses in mice.
IV mutation literature information.
PMID: 
2019
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