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 IV mutation literature information.


  Crystallization and preliminary X-ray diffraction studies of a surface mutant of the middle domain of PB2 from human influenza A (H1N1) virus.
 PMID: 24419622       2014       Acta crystallographica. Section F, Structural biology communications
Abstract: To improve the solubility, a surface double mutant (P453H and I471T) was prepared.


  Conformational polymorphism of m7GTP in crystal structure of the PB2 middle domain from human influenza A virus.
 PMID: 24312396       2013       PloS one
Abstract: Here we report the crystal structure of the middle domain of H1N1 PB2 with or without m(7)GTP at 1.9 A and 2.0 A resolution, respectively, which has two mutations (P453H, I471T) to increase electrostatic potential and solubility.
Introduction: Here we report PB2 middle domain structure (318-483) belonging to subtype H1N1 human influenza with m7GTP (Figure 1), which has two mutations (P453H, I471T) to increase solubility of this domain.
Method: Coordinates and structure factors of PB2 middle domain with two amino acids mutation (P453H and I471T) have been deposited in the Protein Data Bank.



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