Abstract: Mutations were found in HA (A135 T, T136S, and T160 A [H3 numbering]), M1 (N30D and T215 A), NS1 (P42S and D97 E), PB2 (R389 K), and PA (N383D) proteins; these mutations have been shown to be related to mammalian adaptation and changes in virulence of AIVs.
Table: N383D
Discussion: Other mutations including A135 T, T136S, and T160 A in
PA Mutations Inherited during Viral Evolution Act Cooperatively To Increase Replication of Contemporary H5N1 Influenza Virus with an Expanded Host Range.
Discussion: Recently, it has become apparent that PA plays a role in the host adaptation of AI viruses, with mutations identified throughout the PA gene sequence (i.e., A36T, S37A, T85I, G186S, L336M, A343S/T, K356R, N383D, and N409S).
In silico thermodynamic stability of mammalian adaptation and virulence determinants in polymerase complex proteins of H9N2 virus.
Discussion: The substitution N383D in PA found in all viruses under study and may play an important role in the activity of the polymerase and in the accumulation of the PA and PB1 subunits in the nucleus of infected cells.
Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence.
Discussion: Song et al reported that PA N383D contributed to the difference in the polymerase activities of two H5N1 viruses, but could not increase viral virulence, which may be affected by high level of polymerase accumulation in the nucleus of influenza virus-infected cells.
IV mutation literature information.
PMID: 
2021
Poultry science
Browser Board
Co-occurred Entities
Filtrator
ViMRT