Abstract: Human recombinant DC-SIGN (rDC-SIGN) coated ELISA showed that H5N1-PVs bound to DC-SIGN, however, mutation on the
N27Q,
N39Q, and
N181Q significantly reduced this binding (p < 0.05).
Method: The pHW1203-
HA with different N-linked glycosylation mutations including
N26Q,
N27Q,
N39Q,
N170Q,
N181Q,
N209Q,
N302Q,
N500Q,
N599Q and other combination of mutations were generated.
Result: A serial N-glycosylation mutation on
HA extracellular domain (including
HA1
IV mutation literature information.
PMID: 
2021
International journal of molecular sciences
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