IV mutation literature information.


  Phylogenetic Analysis of Hemagglutinin Genes of H9N2 Avian Influenza Viruses Isolated from Chickens in Shandong, China, between 1998 and 2013.
 PMID: 26609523       2015       BioMed research international
Result: 29 out of 35 H9N2 AIVs had leucine (L) at position 226, including all of the isolates between 2005 and 2013 (Table 3).
Discussion: Additionally, 29 out of 35 H9N2 AIVs had leucine (L) at position 226, including all of the isolates between 2005 and 2013.


  Isolation and characterization of H9N2 influenza virus isolates from poultry respiratory disease outbreak.
 PMID: 24790833       2014       SpringerPlus
Discussion: In particular the amino acids glutamine (Q) or leucine (L) at position 226 (H3 numbering, 234H9 numbering) plays a key role in avian and human virus-like receptor specificity respectively.
Discussion: The presence of leucine (L) at position 226 is associated with mammalian adaptation avian influenza virus.



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