literature

IV mutation literature information.

Prediction of avian influenza A binding preference to human receptor using conformational analysis of receptor bound to hemagglutinin.

PMID: 19958488 2009 BMC genomics

Abstract: RESULTS: Molecular dynamics simulation was employed to study the interactions between receptor models and hemagglutinin proteins from H5N1 strains A/Duck/Singapore/3/97, mutated A/Duck/Singapore/3/97 (Q222L, G224S, Q222L/G224S), A/Thailand/1(KAN-1)/2004, and mutated A/Thailand/1(KAN-1)/2004 (L129V/A134V).

Introduction: A Kan-1 derived strain with further HA mutations L129V and A134V is considered a quasi-species which exhibited higher selectivity toward human cell type receptor.

Result: In contrast, the cis conformation was observed (Phi = +60 degrees) for the majority of the simulation time when the analogs bound with Puer

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