literature

IV mutation literature information.

Potential Pandemic of H7N9 Avian Influenza A Virus in Human.

PMID: 30533399 2018 Frontiers in cellular and infection microbiology

Result: These were also found to have very high proportions in both human- and avian-isolated H7N9 (Supplementary Table 2) as follows: three amino acids in HA (I116M, N154D, I198V, Figure 1A); four in NA (M26I, R143K, T223I, N390K, Figure 1B); 10 in PB2 (T63I, L89V, K251R, G309D, T339K, Q368R, H447Q, I471T, R477G,

Crystallization and preliminary X-ray diffraction studies of a surface mutant of the middle domain of PB2 from human influenza A (H1N1) virus.

PMID: 24419622 2014 Acta crystallographica. Section F, Structural biology communications

Abstract: To improve the solubility, a surface double mutant (P453H and I471T) was prepared.

Conformational polymorphism of m7GTP in crystal structure of the PB2 middle domain from human influenza A virus.

PMID: 24312396 2013 PloS one

Abstract: Here we report the crystal structure of the middle domain of H1N1 PB2 with or without m(7)GTP at 1.9 A and 2.0 A resolution, respectively, which has two mutations (P453H, I471T) to increase electrostatic potential and solubility.

Introduction: Here we report PB2 middle domain structure (318-483) belonging to subtype H1N1 human influenza with m7GTP (Figure 1), which has two mutations (P453H, I471T) to increase solubility of this domain.

Method: Coordinates and structure factors of PB2 middle domain with two amino acids mutation (P453H and I471T) have been deposited in the Protein Data Bank.

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