ViMRT
}  
 
Home   
< Docs   

 IV mutation literature information.


  Deep sequencing of the transcriptome from murine lung infected with H5N8 subtype avian influenza virus with combined substitutions I283M and K526R in PB2 gene.
 PMID: 33309772       2021       Infection, genetics and evolution
Abstract: Especially, PB2-I283M-K526R mutation strongly induced a sharp expression of cytokine storm-related genes, including MX1, CXCL10, and IFN-gamma, performed by qRT-PCR.
Abstract: Here, RNA-seq method was used to analyze the global host response of murine lungs after infecting with parental r-JY virus and JY-PB2-I283M-K526R mutant virus.
Abstract: Taken together, our data demonstrated that PB2-I283M-K526R of H5N8 subtype HPAIV exacerbated the innate immune response and the level of cell apoptosis, which might be a key pathogenic mechanism for the enhanced pathogenicity of mutants in mammals.



Browser Board

 Co-occurred Entities




   Filtrator