Result: Unexpectedly, we found that protein expression of NS1 mutant I178V was less than that of the other seven mutants (Figure 5A).
Discussion: Here, to identify new residues in H7N9 NS1 that are associated with virus virulence, we screened eight substitutions including R55E, H63Q, E70K, P87S, S114P, Discussion: In addition, we also identified that I178V mutation led to NS1 degradation through proteasome pathway.
Discussion: We postulated that I178V mutation might have altered the structure of the NS1 protein and caused its degradation.
IV mutation literature information.
PMID: 
2018
Veterinary research
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