Abstract: The emergence and global spread in 2007/2008 of A(H1N1) influenza viruses showing clinical resistance to oseltamivir due to neuraminidase (NA) H275Y substitution, in the absence of drug pressure, warrants continued vigilance and monitoring for similar viruses.
Abstract: Those showing HRI were A(H1N1)pdm09 with NA H275Y (n=18), A(H3N2) with NA E119V (n=3) or NA R292K (n=1) and B/Victoria-lineage with NA H273Y (n=2); amino acid position numbering is A subtype and B type specific.
Method: Because former seasonal A(H1N1) viruses possessing NA
Development and clinical testing of a simple, low-density gel element array for influenza identification, subtyping, and H275Y detection.
PMID: 25066276
2014
Journal of virological methods
Introduction: The objectives of this study were therefore to develop a simplified gel element microarray test for influenza A and B virus detection, influenza A sub typing, and H275Y variant detection in both seasonal and pandemic influenza A/H1N1 subtypes, with an emphasis on minimizing overall microarray test complexity for diagnostic ease-of-use and eventual translation into a sample-to-answer, fully automated system.
Method: 3.8 Influenza typing, subtyping, and H275Y variant detection.
Method: Assay targets included primers and probes for influenza A (M gene), influenza B (NS gene), seasonal H1 and H3 subtyping (HA gene), pandemic influenza A H1 (2009 pandemic NP and HA genes), H275Y variants of seaso
Prolonged shedding of pandemic influenza A (H1N1) 2009 virus in a pancreas-after-kidney transplant recipient.
Discussion: Previously, we showed that the NA mutation H275Y in first-wave virus conferred a replicative cost that was not detected by growth curve analysis but only by competition assay.
Characterization of human Influenza Viruses in Lebanon during 2010-2011 and 2011-2012 post-pandemic seasons.
Abstract: Nonetheless, all 2011-2012 H1N1p isolates had three mutations (V241I, N369K, and N386S) in the NA gene that were suggested to be permissive of the H275Y mutation, which confers resistance to oseltamivir.
Influenza A H1N1pdm 2009 Virus in Paraguay: Nucleotide Point Mutations in Hemagglutinin and Neuraminidase Genes are not Associated with Drug Resistance.
Abstract: Neither the mutation related to exacerbation of disease (D239G in hemagglutinin) nor that related to antiviral resistance (H275Y in neuraminidase), both detected in neighboring countries, were found.
Introduction: In Argentina, a study carried out in 2009 isolated six oseltamivir-resistant strains containing the NA H275Y mutation, from 262 cases with mild to severe forms of the disease; none of the mutations in HA or NA were related to fatal cases.
Introduction: We did not find the NA D199N mutation associated with an increase in oseltamivir resistance published in both seasonal and H5N1 virus strains, or the
A multiplex real-time PCR assay for detection of oseltamivir-resistant strains of influenza virus.
PMID: 32215120
2014
Central European journal of biology
Abstract: The resistance against this drug has probably developed through antigenic drift by a point mutation in one amino acid at position 275 (H275Y).
Evaluation of influenza virus antiviral susceptibility testing in Europe: results from the first external quality assessment exercise.
Abstract: CONCLUSIONS: Detection of NA-H275Y in A(H1N1) viruses was achieved by most laboratories.
Genetic characterization of influenza virus circulating in Brazilian pigs during 2009 and 2010 reveals a high prevalence of the pandemic H1N1 subtype.
PMID: 23280098
2013
Influenza and other respiratory viruses
Result: None of the 2009-2010 Brazilian pandemic H1N1 isolates had the H275Y or N295S substitutions in NA (data not shown), which are known to confer resistance to oseltamivir.26 .
Result: None of the 2009-2010 Brazilian pandemic H1N1 isolates had the H275Y or N295S substitutions in NA (data not shown), which are known to confer resistance to oseltamivir.26.
Influenza virus A(H1N1)pdm09 hemagglutinin polymorphism and associated disease in southern Germany during the 2010/11 influenza season.
Abstract: The H275Y mutation in the influenza virus neuraminidase gene, known to confer resistance to the neuraminidase inhibitor oseltamivir, was detected in one patient.
Method: For the detection of the oseltamivir-resistance-associated mutation H275Y, a commercially available assay (TIB-Molbiol, Berlin, Germany) was used according to the manufacturer's instructions.
Result: The oseltamivir-resistance-associated mutation H275Y was detected in 1 (20 %) of the 5 treated patients, a one-year-old child with a genetic disorder, who was treated for 21 days with oseltamivir.
Table: H275Y
Discussion: Finally, the oseltamivir-resistance-associated mutation H275Y was detected only once in our study population.
IV mutation literature information.
PMID: 
2014
Antiviral research
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