Introduction: Comparative studies and competition trials have demonstrated that the H275Y mutation is accompanied by only a minor reduction in fitness, and evidence of community transmission has recently been observed.
Introduction: Experimental measurements of IC50 values revealed that the H275Y mutation reduces susceptibility to both oseltamivir (980-fold for A/Quebec/144147/09) and peramivir (660-fold).
Introduction: However in recent years some resistance has been reported, and subsequent analysis revealed the presence of the H275Y mutation in a large number of these cases.
Introduction: Initial studies showed that the H1N1pdm09 strain did not bear the H275Y mutation and was susceptible to NA inhibitors.
Introduction: The resistance in the seasonal strain, due to a
Virological characterization of influenza H1N1pdm09 in Vietnam, 2010-2013.
PMID: 25966032
2015
Influenza and other respiratory viruses
Abstract: One isolate from 2011 and one isolate from 2013 had a predicted H275Y substitution in the neuraminidase molecule, which was associated with reduced susceptibility to oseltamivir in a NAI assay.
Introduction: In addition, substitutions <
Result: A significant mutation at H275Y related to reduced susceptibility to oseltamivir was found in two isolates in 2011 and 2013 located in groups 7A and 5 (Figure4).
Discussion: Two oseltamivir-resistant A/H1N1pdm09 isolates in 2011 and 2013 were detected by neuraminidase inhibition (NAI) test and Sanger sequence NA gene (H275Y); in total, 11 cases of Vietnamese oseltamivir-resistant A/H1N1pdm09 isolates have been identified between 2009 and 2013.
Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance.
PMID: 25742269
2015
Memorias do Instituto Oswaldo Cruz
Abstract: Consequently, OST-resistant strains, carrying the mutation H275Y, emerged in the years after the pandemics, with a prevalence of 1-2%.
Abstract: Importantly, the change D344N, also predicted to compensate loss of fitness imposed by H275Y mutation, was found in Brazil, but not in other countries in 2013.
Abstract: To spread in community settings, H275Y mutants must contain additional mutations, collectively called permissive mutations.
Result: 1) (H275Y viruses in red).
Result: 1) and are predicted to compensate for the negative effects of H275Y change (Hurt et al.
Result: Although low prevalence of H275Y viruses with permissive mutations in the <
Table: H275Y
Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2013-2014.
Introduction: Additional NA substitutions (R222Q, V234M, D344N and D354G) compensated for the detrimental effect of the H275Y substitution on virus fitness, allowing the virus to spread efficiently.
Introduction: Animal models have shown that A(H1N1)pdm09 H275Y viruses with additional NA amino acid substitutions, V241I and N369K, have increased replication and transmission fitness.
Introduction: Despite >99% of circulating viruses being sensitive to all four NAIs during the 2012-2013 period, localised community circulation of influenza viruses with RI or HRI has occurred in recent years, most nota
Identification of novel compounds against an R294K substitution of influenza A (H7N9) virus using ensemble based drug virtual screening.
PMID: 25589893
2015
International journal of medical sciences
3Introduction: Single amino acid change known as the ""H275Y"" mutation in 2009 H1N1 flu virus and ""R292K"" mutation in influenza A virus is conferred by drug resistance."
Phylogenetic analysis of the neuraminidase gene of pandemic H1N1 influenza A virus circulating in the South American region.
Abstract: 3.4% of the strains enrolled in these studies carried the H275Y substitution that confers resistance to oseltamivir.
Influenza A H1N1pdm 2009 Virus in Paraguay: Nucleotide Point Mutations in Hemagglutinin and Neuraminidase Genes are not Associated with Drug Resistance.
Abstract: Neither the mutation related to exacerbation of disease (D239G in hemagglutinin) nor that related to antiviral resistance (H275Y in neuraminidase), both detected in neighboring countries, were found.
Introduction: In Argentina, a study carried out in 2009 isolated six oseltamivir-resistant strains containing the NA H275Y mutation, from 262 cases with mild to severe forms of the disease; none of the mutations in HA or NA were related to fatal cases.
Introduction: We did not find the NA D199N mutation associated with an increase in oseltamivir resistance published in both seasonal and H5N1 virus strains, or the
Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom.
Discussion: Previously, we showed that the NA mutation H275Y in first-wave virus conferred a replicative cost that was not detected by growth curve analysis but only by competition assay.
Characterization of human Influenza Viruses in Lebanon during 2010-2011 and 2011-2012 post-pandemic seasons.
Abstract: Nonetheless, all 2011-2012 H1N1p isolates had three mutations (V241I, N369K, and N386S) in the NA gene that were suggested to be permissive of the H275Y mutation, which confers resistance to oseltamivir.
Characterization of drug-resistant influenza virus A(H1N1) and A(H3N2) variants selected in vitro with laninamivir.
PMID: 24957832
2014
Antimicrobial agents and chemotherapy
Abstract: More specifically, it retained activity against oseltamivir-resistant H275Y and N295S A(H1N1) variants and the E119V A(H3N2) variant.
IV mutation literature information.
PMID: 
2015
PloS one
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