Characterization of Influenza B Virus Variants with Reduced Neuraminidase Inhibitor Susceptibility.
PMID: 30201817
2018
Antimicrobial agents and chemotherapy
8Discussion: In the future, it is possible that the NA variants examined in our study may gain additional ""permissive"" mutations that improve their fitness, as was observed with the H275Y NA substitution in seasonal H1N1 viruses."
Introduction: The H273Y NA substitution in influenza B viruses occurs at the equivalent residue to that of the H275Y NA substitution in influenza A(H1N1) viruses, which was present in the oseltamivir-resistant influenza A(H1N1) viruses that spread globally in 2008/2009.
An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses.
Introduction: In fact, the 2008-2009 seasonal influenza viruses with the H275Y NA mutation were completely resistant to the only orally bioavailable drug, oseltamivir.
Community- and hospital-acquired infections with oseltamivir- and peramivir-resistant influenza A(H1N1)pdm09 viruses during the 2015-2016 season in Japan.
Abstract: Overall, the prevalence of the H275Y A(H1N1)pdm09 viruses was 1.8 % (5/282).
Abstract: We report five cases of community- and hospital-acquired infections with oseltamivir- and peramivir-resistant A(H1N1)pdm09 viruses possessing the neuraminidase (NA) H275Y mutation during January-February 2016 in Japan.
Introduction: Five of A(H1N1)pdm09 isolates (5/282, 1.8 %) were found to possess the H275Y mutation.
Introduction: Further studies are warranted to better assess clinical effectiveness of oseltamivir and peramivir against the H275Y A(H1N1)pdm09 varian
Introduction: demonstrated in a small number of pediatric patients that oseltamivir and peramivir retain the clinical effectiveness against the H275Y mutant virus.
Therapeutic efficacy of peramivir against H5N1 highly pathogenic avian influenza viruses harboring the neuraminidase H275Y mutation.
Abstract: Evaluation of the in vivo antiviral activity showed that a single intravenous treatment of peramivir (10 mg/kg) prevented lethality in mice infected with wild-type H5N1 virus and also following infection with H5N1 virus with the H275Y mutation after a 5 day administration of peramivir (30 mg/kg).
Abstract: In H5N1 viruses containing the NA H275Y mutation, the antiviral activity of peramivir against the variant was lower than that against the wild-type.
Abstract: These results suggest that peramivir has therapeutic activity against HPAI viruses even if the virus harbors the NA H275Y mutation.
Development of oseltamivir and zanamivir resistance in influenza A(H1N1)pdm09 virus, Denmark, 2014.
Abstract: Day 149 when the patient had almost completed the second zanamivir treatment, mixes of the following resistance mutations were detected; H275Y(65.1%), I223R(9.2%), and E119G(89.6%), accompanied by additional mutations, showing a more complex viral population in the long-term treated patient.
Abstract: In a sample collected 15 days after the end of the first treatment with oseltamivir (Day 20 post-symptom onset), oseltamivir resistance was detected (mutation H275Y with 60.3% frequency by NGS).
Introduction: Among these, two well characterised mutations are the H275Y mutation which results in viruses with highly reduced inhibition by oseltamivir and the I223R mutation which results in reduced inhibition by both oseltamivir and zanamivir.
Discussion: By addit
Antigenic and genetic characterization of influenza viruses circulating in Bulgaria during the 2015/2016 season.
PMID: 28132927
2017
Infection, genetics and evolution
5Result: In the National Laboratory ""Influenza and ARD"", all 210 detected A(H1N1)pdm09 viruses were analyzed by real-time RT-PCR with respect to the H275Y oseltamivir resistance substitution : all viruses carried 275H indicative of retained susceptibility."
Method: Screening of A(H1N1)pdm09 viruses for the presence of point mutations conferring H275Y oseltamivir resistance was carried out using a Real Time RT-PCR assay tha
Discussion: Globally, oseltamivir resistance of A(H1N1)pdm09 viruses due to NA H275Y substitution has been low (~ 1% of viruses tested) and resistance of A(H3N2) and B viruses is extremely rare.
Discussion: In our previous study, we detected a single A(H1N1)pdm09 virus carrying NA H275Y substitution in a child treated with oseltamivir.
Expeditious Lead Optimization of Isoxazole-Containing Influenza A Virus M2-S31N Inhibitors Using the Suzuki-Miyaura Cross-Coupling Reaction.
PMID: 28182419
2017
Journal of medicinal chemistry
Result: The A/Washington/29/2009 (H1N1) and A/Denmark/528/2009 (H1N1) viruses were chosen because they are representative examples of multidrug-resistant influenza A viruses and these two strains are resistant to both amantadine and oseltamivir due to AM2-S31N and H275Y mutations in their AM2 and neuraminidase genes, respectively.
Design, in silico studies, synthesis and in vitro evaluation of oseltamivir derivatives as inhibitors of neuraminidase from influenza A virus H1N1.
PMID: 28182988
2017
European journal of medicinal chemistry
Abstract: The emergence of NA mutations, such as H275Y, has led to great resistance against neuraminidase inhibitors, including oseltamivir and zanamivir.
Evolution of the neuraminidase gene of seasonal influenza A and B viruses in Thailand between 2010 and 2015.
Abstract: We initially examined oseltamivir resistance (characterized by the H275Y mutation in the NA gene) in 485 A(H1N1)pdm09 strains circulating in Thailand and found that 0.82% (4/485) had this substitution.
Result: Between 2009 and 2015, 6.4% of viruses circulating in Thailand of A(H1N1)pdm09 were H275Y strains, whereas, 1.4% had an S247N mutation.
Result: In contrast, the H275Y oseltamivir-resistant strains that were circulated in other years were clustered separately: clade 1 (2009 season), clades 2, 5, and 7 (2010 season), clade 6A (2012 season), and clade 6B (2014 season).
Result: In the years after the influenza A virus pandemic of 2010, 485 samples tested positive for A(H1N1)pdm09 of which 4 (0.82%) were oseltamivir-resistant (H275Y) strains (S1 Fig and S
Neuraminidase Gene Variations in Influenza A(H1N1)pdm09 Virus among Patients Admitted to Refferal Pulmonary Hospital, Tehran, Iran in 2009-2013.
Abstract: Meanwhile, H275Y substitution, related to oseltamivir resistance, was detected in 3 isolates.
Introduction: In addition, we performed a study on the prevalence of oseltamivir resistance and H275Y mutations in pandemic H1N1 strains during 2009-2010 season, using real-time probe-based polymerase chain reaction (PCR) method.
Introduction: On the other hand, resistance mutations (H275Y, E119V/G, and I22V) have been reported in in vivo and in vitro models.
Table: H275Y
Discussion: Meanwhile, H275Y substitution, detected in this study, was of phylogenic importance and led to speciation of influenza strains in the phylogenetic tree (Figure 1).
Discussion: The present study showed that 3 isolates (2 isolat
IV mutation literature information.
PMID: 
2018
Antimicrobial agents and chemotherapy
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