Abstract: No H275Y mutation in NA protein was found.
Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y.
PMID: 21865430
2011
Journal of clinical microbiology
Abstract: An isolated-probe-asymmetric amplification PCR (Roche LightCycler v2.0) and high-resolution melting (HRM) method using unlabeled probes and amplified products (Idaho LightScanner 32) was designed and optimized to detect and estimate the proportion of H275Y mutants in influenza A/H1N1/2009 virus samples.
Abstract: The melting peaks of the H275Y-specific unlabeled probe for the wild-type A/H1N1/2009 and H275Y mutant viruses were clearly distinguishable at 65.5 C and 69.0 C, respectively, at various ratios of wild-type/mutant virus population standards.
Abstract: The single-nucleotide variation 823C to T (His275Tyr), responsible for oseltamivir drug resistance has been detected in some isolates of the influenza A/H1N1/2009 virus.
Multidrug resistant 2009 A/H1N1 influenza clinical isolate with a neuraminidase I223R mutation retains its virulence and transmissibility in ferrets.
Introduction: An isoleucine to arginine substitution at positi
Discussion: A I223V/H275Y double mutant was detected in two closely residing patients who were treated with OS.
Discussion: Besides the I223R single mutant virus studied here, an I223R/H275Y double mutant was detected in an immune suppressed patient treated with OS and ZA.
Discussion: In combination with the H275Y change, these viruses demonstrated resistance patterns similar to the I223R/H275Y mutant.
Discussion: Interestingly, neighboring residue 247 has been linked to NAI resistance in combination with the H275Y mutation.
First Fatal Oseltamivir-Resistant 2009 Pandemic Influenza A (H1N1) Case in an Adult in Korea.
Abstract: An H275Y mutation was detected in the neuraminidase gene sequence.
Conclusion: Sequence analysis performed at the Korea Centers for Disease Control and Prevention revealed an H275Y neuraminidase gene mutation, as described elsewhere.
Role of permissive neuraminidase mutations in influenza A/Brisbane/59/2007-like (H1N1) viruses.
Abstract: All studied mutations reduced the cell surface NA activity compared to WT with the maximum reduction being obtained for the H275Y/Q222R mutant.
Abstract: Comparable infectivity and transmissibility were seen between the WT and the H275Y mutant in ferrets whereas the H275Y/Q222R mutant was associated with significantly lower lung viral titers.
Abstract: Here, we rescued a recombinant Bris07-like WT virus and 4 NA mutants/revertants (H275Y, H275Y/Q222R, H275Y/M234V and H275Y/N344D) an
Virological surveillance and antiviral resistance of human influenza virus in Argentina, 2005-2008.
PMID: 22358415
2011
Revista panamericana de salud publica
Abstract: Oseltamivir resistance was observed in 12 (34.3%) of the 35 A(H1N1) strains from 2008; all of them carried the mutation H275Y in their neuraminidase sequence.
Persistent oseltamivir-resistant pandemic influenza A/H1N1 infection in an adult with cystic fibrosis.
Abstract: The influenza virus was positive for the H275Y oseltamivir-resistance mutation despite the patient never having received oseltamivir.
[Cuban strategy for the molecular characterization of the pandemic influenza A virus (H1N1)].
PMID: 23437533
2011
Revista cubana de medicina tropical
Abstract: RESULTS: The third strategy provided the most comprehensive results such as differential diagnosis, the surveillance of the D222G/E mutation in hemagglutinin and Tamiflu-resistant H275Y viral variants.
Prevalence of Oseltamivir-Resistant 2009 H1N1 Influenza Virus among Patients with Pandemic 2009 H1N1 Influenza infection in NRITLD, Tehran, Iran.
Abstract: MATERIALS AND METHODS: In a retrospective cross-sectional study, respiratory tract specimens of confirmed cases of 2009 H1N1 influenza referred to the Masih Daneshvari Hospital were analyzed for presence of H275Y mutation.
Abstract: RESULTS: From November 2009 through March 2010, oseltamivir-resistant 2009 H1N1 infection was observed and confirmed in 4 patients (including 2 immunocompromised patients) by performing H275Y mutation molecular testing.
Abstract: The H275Y mutation
Introduction: Oseltamivir-resistant infection with the 2009 pandemic influenza A (H1N1) virus that is conferred by the H275Y substitution in the neuraminidase (NA) has so far been described in 298 patients by the WHO.
IV mutation literature information.
PMID: 
2011
Antiviral research
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