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 IV mutation literature information.


  Consecutive influenza surveillance of neuraminidase mutations and neuraminidase inhibitor resistance in Japan.
 PMID: 30548432       2019       Influenza and other respiratory viruses
Abstract: Even in Japan, no spread of NAI-resistant viruses has been observed, and A/H1N1pdm09 viruses carrying H275Y remain limited.
Abstract: Four of the five mutations in the catalytic sites of A/H1N1pdm09 consisted of H275Y, which was related to high resistance to oseltamivir and peramivir.
Introduction: These NAIs exert their antiviral function by binding to the enzymatic catalytic sites of influenza surface protein NA.1 In the 2007-2008, oseltamivir-resistant seasonal A/H1N1 viruses carrying NA amino acid (AA) mutation Result: With regard to the substantial RI/HRI-related AA mutations detected in this study, four A/H1N1pdm09 viruses displaying HRI by oseltamivir and RI by peramivir contained H275Y mutations.


  Molecular characterization of influenza A(H1N1)pdm09 in Cameroon during the 2014-2016 influenza seasons.
 PMID: 30640922       2019       PloS one
Result: None of the strains possessed the H275Y mutation that has been reported clinically to cause highly reduced inhibition to NAIs.
Discussion: These results are however different from that noted on H1N1 strains collected between 2007 and 2008 from Cameroon in which the H275Y mutation peculiar of resistance to NAIs was observed despite the non-exposition to this antiviral.


  Effect of influenza H1N1 neuraminidase V116A and I117V mutations on NA activity and sensitivity to NA inhibitors.
 PMID: 31228489       2019       Antiviral research
Abstract: The efficiencies of NAs with E119A, H275Y, and N295S mutations to catalyze all substrates were ~19.4% of the CA/04 NA.
Abstract: We compared the impact of V116A and I117V on the functional properties of NA and compared these mutations with that of previously reported NAI-resistant mutations, E119A, H275Y, and N295S.


  Superb Specific, Ultrasensitive, and Rapid Identification of the Oseltamivir-Resistant H1N1 Virus: Naked-Eye and SERS Dual-Mode Assay Using Functional Gold Nanoparticles.
 PMID: 35021372       2019       ACS applied bio materials
Abstract: By measuring the SERS signals, we could detect the pH1N1/H275Y mutant virus with a detection limit of 10 PFU.
Abstract: Herein, we report specific and ultrasensitive detection of oseltamivir-resistant (pH1N1/H275Y mutant) virus using functional Au nanoparticles (NPs).
Abstract: Importantly, the pH1N1/H275Y mutant virus could be detected by using the functional Au NPs even in a mixture of mutant and wild-type viruses with a ratio of 1/100.


  Diagnosis of Tamiflu-Resistant Influenza Virus in Human Nasal Fluid and Saliva Using Surface-Enhanced Raman Scattering.
 PMID: 31407570       2019       ACS sensors
Abstract: By combining SERS-active urchin Au nanoparticles and oseltamivir hexylthiol, an excellent receptor for the pH1N1/H275Y mutant virus, we detected the pH1N1/H275Y virus specifically and sensitively in human saliva and nasal fluid samples.


  Antiviral Activity of Benzoic Acid Derivative NC-5 Against Influenza A Virus and Its Neuraminidase Inhibition.
 PMID: 31842256       2019       International journal of molecular sciences
Result: As in the case of H1N1-H275Y, the inhibition rate of NC-5 at 80 muM was 72.9%, while that of OC was only 4.0% (Figure 3F).
Result: As shown in Figure 5E and Figure 6E, severe hyperemia appeared in the alveolar walls, and the spaces between the alveolar walls were filled with moderate inflammatory infiltrates of neutrophils, macrophages and lymphocytes in the H1N1 and H1N1-H275Y virus-infected models as well as in mice given OS following infection with H1N1-H275Y.
Result: Effective Protection by NC-5 in Mice Infected with Influenza Virus A/FM/1/47 (H1N1) and Oseltamivir-Resistant Mutant A/FM/1/47 (H1N1-H275Y)

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