Introduction: Thus, all earlier H1N1 viruses with an H275Y mutation were referred to as H274Y.
Introduction: reported a mouse-adapted influenza A/WSN/33 (H1N1) H275Y (referred to as H274Y in the publication) infection model in mice.
Molecular basis of drug resistance in A/H1N1 virus.
PMID: 22978683
2012
Journal of chemical information and modeling
Abstract: In this study, free-energy perturbation was used to evaluate the relative binding free energies of Tamiflu and Relenza with H274Y, N294S, and Y252H neuraminidase mutants.
Oseltamivir-resistant influenza A and B viruses pre- and postantiviral therapy in children and young adults with cancer.
PMID: 21048522
2011
The Pediatric infectious disease journal
Introduction: Most H1N1 viruses circulating since the 2007-2008 influenza season have a histidine to tyrosine substitution at residue 274 (H274Y), which is also associated with resistance to oseltamivir but not zanamivir.
Genotypic and phenotypic resistance of pandemic A/H1N1 influenza viruses circulating in Germany.
Discussion: The neuraminidase H275Y (H274Y in N2 numbering) mutation known to confer resistance to oseltamivir (Tamiflu ) and to peramivir, a drug used intravenously under an emergency use authorization, also was detected but only sporadically (n = 5) in 3 distinct clades/regions: namely clade 7 - AB (3); clade 3 - PQ (1) and clade 6 - ON (1).
Influenza and other respiratory viruses in three Central American countries.
PMID: 21306576
2011
Influenza and other respiratory viruses
Abstract: It also showed that the mutation H274Y conferring resistance to oseltamivir was first detected in Honduran influenza A/H1N1 strains at the beginning of 2008.
Discussion: Our previous findings 8 showed that the mutation H274Y conferring resistance to oseltamivir began to be detected in influenza A/H1N1 strains circulating in Central America (Honduras) at the beginning of 2008.
Effect of an asparagine-to-serine mutation at position 294 in neuraminidase on the pathogenicity of highly pathogenic H5N1 influenza A virus.
Abstract: However, unlike viruses with the NA H274Y mutation, the properties of viruses possessing NA N294S are not well understood.
Abstract: Like the histidine-to-tyrosine substitution at position 274 in neuraminidase (NA H274Y), an asparagine-to-serine mutation at position 294 in this protein (NA N294S) confers oseltamivir resistance to highly pathogenic H5N1 influenza A viruses.
Combinatorial effect of two framework mutations (E119V and I222L) in the neuraminidase active site of H3N2 influenza virus on resistance to oseltamivir.
PMID: 21422222
2011
Antimicrobial agents and chemotherapy
Abstract: Among the viruses produced, the E119D+I222L mutant virus was not able to grow without bacterial NA complementation and the D198N+I222L mutant and H274Y+I222L mutant were not stable after passages in MDCK cells.
Abstract: To look at the possibility of an increased effect on the resistance phenotype of a combination of framework mutations, known to confer resistance to oseltamivir or zanamivir, with limited effect on virus fitness, we constructed 4 viruses by reverse genetics in the A/Moscow/10/99 H3N2 background containing double mutations in their neuraminidase genes: E119D+I222L, E119V+ PMID: 21455300
2011
PloS one
Introduction: The H275Y mutation in the neuraminidase (NA) gene (H274Y in N2 numbering), first described in 2000, is the most frequent mutation associated with oseltamivir-resistance in the N1 subtype, but it had long been thought to critically reduce viral fitness.
Oseltamivir-resistant influenza viruses get by with a little help from permissive mutations.
PMID: 21504394
2011
Expert review of anti-infective therapy
Introduction: NA residue 274 is located near the enzymatic site of NA and the H274Y substitution causes a structural change in NA that reduces oseltamivir-binding affinity.
Introduction: NAI-resistant viruses possessing a histidine to tyrosine substitution at NA residue 274 (H274Y, N2 numbering) were isolated from humans in a clinical trial designed to test the efficacy of oseltamivir.
Introduction: However, H1N1 viruses possessing the oseltamivir-resistant H274Y mutation appeared during the 2007-2008 IAV season and these viruses became the dominant seasonal H1N1 strain by the 2008-2009 season.
Introduction: These viruses did not have the same replication defect seen earlier with older H1N1 vir
IV mutation literature information.
PMID: 
2012
Antiviral research
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