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 IV mutation literature information.


  Neuraminidase sequence analysis and susceptibilities of influenza virus clinical isolates to zanamivir and oseltamivir.
 PMID: 12821478       2003       Antimicrobial agents and chemotherapy
Abstract: The drug susceptibilities of known zanamivir- and oseltamivir-resistant viruses with the NA mutations E119V, R292K, H274Y, and R152K fell well outside the 95% confidence limits of the IC(50)s for all natural isolates.


  Dynamic residue interaction network analysis of the oseltamivir binding site of N1 neuraminidase and its H274Y mutation site conferring drug resistance in influenza A virus.
 PMID: 12103431       2002       Antiviral research
Abstract: Virus carrying H274Y NA enzyme selected in vivo has reduced sensitivity to oseltamivir carboxylate.
Abstract: Virus carrying a H274Y mutation is unlikely to be of clinical consequence in man.


  Mechanism by which mutations at his274 alter sensitivity of influenza a virus n1 neuraminidase to oseltamivir carboxylate and zanamivir.
 PMID: 12435681       2002       Antimicrobial agents and chemotherapy
Abstract: An influenza A/H1N1 variant selected in vitro with reduced susceptibility to oseltamivir carboxylate contains a His274Tyr mutation.
Abstract: Loss of this slow-binding inhibition in the His274Tyr and His274Phe mutant NA but not in His274Asn, His274Gly, His274Ser, or His274Gln supports the conclusion that the conformational change of Glu276 is restricted in the His274Tyr and His274Phe mutant NA upon oseltamivir carboxylate binding.
Abstract: Substitution of His274 with Tyr in influenza A/Tokyo/3/67 (H3N2) recombinant NA


  Selection of influenza virus mutants in experimentally infected volunteers treated with oseltamivir.
 PMID: 11170976       2001       The Journal of infectious diseases
Abstract: They bore a substitution His274Tyr in the NA.


  Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants.
 PMID: 11709315       2001       Antimicrobial agents and chemotherapy
Abstract: The oseltamivir-selected variant (N1) with the His274-->Tyr substitution exhibited resistance to oseltamivir carboxylate (IC(50) = 400 nM) and to RWJ-270201 (IC(50) = 40 nM) but retained full susceptibility to zanamivir (IC(50) = 1.5 nM).



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