Result: The position 35 was near the endonuclease active site 41 of PA (Yuan et al., 2009), whether the amino acid mutation PA(F35S) restricted the endonuclease activity of PA to some extent under thermal stress needed to be identified.
Result: Virus C4/W1 grew efficiently in chickens and could be detected in tracheal swabs, cloacal swabs and lungs of inoculated chickens with high viral titers at 3 and 5 days p.i.; virus ts-C4/W1 couldn't be detected in any swabs or lungs of the inoculat
Result: with 0.2 ml 106 EID50 of the virus C4/W1-PA (F35S), ts-C4/W1 or 0.2 ml PBS.
Result: with 50 mul 106 EID50 of virus C4/W1-PA (F35S), ts-C4/W1 or C4/W1.
IV mutation literature information.
PMID: 
2018
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