literature

IV mutation literature information.

A novel I221L substitution in neuraminidase confers high-level resistance to oseltamivir in influenza B viruses.

PMID: 24795482 2014 The Journal of infectious diseases

Introduction: The most frequent substitutions responsible for oseltamivir resistance in vivo correspond to H275Y, E119V/I, and D197N/E/Y for N1, N2, and influenza B virus neuraminidases, respectively.

Discussion: As for the I223V/R and H275Y substitutions in N1, the N2-I222V substitution alone confers a slight increase in oseltamivir IC50 but acts in synergy with E119V (in N2) to yield highly reduced inhibition by oseltamivir.

Study of oseltamivir and zanamivir resistance-related mutations in influenza viruses isolated from wild mallards in Sweden.

PMID: 24558492 2014 PloS one

Method: The literature describing NAI resistance mutations has been reviewed, whereupon nine OC (V116A, I117V, E119V, D198N, I222V, H274Y, R292K, N294S and I314V) and ten ZA (V116A, R118K, E119G/A/D, Q136K, D151E/G/N, R152K, R224K, E276D, R292K and R371K)

Generation and Characterization of Recombinant Influenza A(H1N1) Viruses Resistant to Neuraminidase Inhibitors.

PMID: 24524021 2013 Osong public health and research perspectives

Abstract: RESULTS: NA-inhibition assays showed that all the single and double mutants containing the Y275 except the single Y275-E119V mutant conferred important levels of resistance to oseltamivir, whereas all the single, double, and triple mutants containing the E119V mutation were associated with the resistance to zanamivir.

Method: To investigate mutations at NA key residues (N1 numbering: I117V, I117M, E119V, I223V, Y275H, R293K, N295S, and S334N), site-directed mutagenesis was conducted on the NA gene cloned plasmid using the Quic

Emergence of an oseltamivir-resistant influenza A/H3N2 virus in an elderly patient receiving a suboptimal dose of antiviral prophylaxis.

PMID: 24088848 2013 Journal of clinical microbiology

Abstract: In neuraminidase inhibition assays, the E119V variant showed a 413-fold increase in the 50% inhibitory oseltamivir concentration and grew at titers comparable to those of the wild type in vitro.

Abstract: We report the emergence of an influenza virus A/H3N2-E119V neuraminidase variant from an elderly patient with renal dysfunction who received a suboptimal dose of oseltamivir prophylaxis.

Cell culture-selected substitutions in influenza A(H3N2) neuraminidase affect drug susceptibility assessment.

PMID: 24080660 2013 Antimicrobial agents and chemotherapy

Abstract: Sequence analysis of its NA gene revealed a known oseltamivir-resistance marker, the glutamic acid-to-valine substitution at position 119 (E119V), and an additional change, threonine to isoleucine at position 148 (T148I).

Abstract: Unlike E119V, T148I was not detected in the clinical sample but acquired during viral propagation in MDCK cells.

Resistance mutation R292K is induced in influenza A(H6N2) virus by exposure of infected mallards to low levels of oseltamivir.

PMID: 23951116 2013 PloS one

Introduction: The most common resistance mutations are H274Y (N2 numbering, this numbering is used throughout the paper) in the N1, and R292K or E119V in the N2 group.

Bioluminescence-based neuraminidase inhibition assay for monitoring influenza virus drug susceptibility in clinical specimens.

PMID: 23917311 2013 Antimicrobial agents and chemotherapy

Abstract: Unless the antigenic types were first identified, certain NA variants (e.g., H3N2 with E119V) could be detected among seasonal viruses using the FL assays only.

Occurrence and characterization of oseltamivir-resistant influenza virus in children between 2007-2008 and 2008-2009 seasons.

PMID: 23646055 2013 Korean journal of pediatrics

Method: For the genotypic analysis, mutations of amino acid regions related to drug resistance (E119V, R152K, H274Y, R292K, and N294S) were examined, via sequence analysis of NA gene.

Result: NA gene analysis was conducted on influenza viruses isolated from 51 patients (group A, 29 patients; group B, 22 patients) during the first study period in order to examine the drug resistance-related mutation of NA inhibitor (E119V, R152K, H274Y, R292K, N294S).

Molecular assays for quantitative and qualitative detection of influenza virus and oseltamivir resistance mutations.

PMID: 23597879 2013 The Journal of molecular diagnostics

Abstract: Four assays are included for detection of oseltamivir resistance mutations H275Y in prepandemic and pandemic influenza A/H1N1 and E119V and R292K in influenza A/H3N2 neuraminidase.

Effect of oseltamivir carboxylate consumption on emergence of drug-resistant H5N2 avian influenza virus in Mallard ducks.

PMID: 23459475 2013 Antimicrobial agents and chemotherapy

Abstract: These results indicate that consumption by wild waterfowl of OC in drinking water may promote selection of the E119V resistance mutation in some strains of H5N2 AIV that could contribute to viruses infecting human populations.

Abstract: Virus isolates carrying the E119V mutation displayed in vitro replication kinetics similar to those of the wild-type virus, but in vivo, the E119V virus rapidly reverted back to wild type in the absence of OC, and only the wild-type parental strain was transmitted to contact ducks.

Abstract: We detected development of virus variants carrying a known molecular marker of oseltamivir resistance (neuraminidase E119V) in 4 out of 6 mallards infected with A/Mallard/Minnesota/182742/1998 (H5N2) and exposed to 1,000 ng/liter OC.

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