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 IV mutation literature information.


  Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2015-2016.
 PMID: 28802866       2017       Antiviral research
Method: E119V is known to confer HRI by oseltamivir, while R292K confers HRI by oseltamivir/peramivir and RI by zanamivir/laninamivir.
Method: Of 815 A(H3N2) NA sequences analysed, one (0.1%), collected in the United Kingdom, had E119V AAS (Table S4).
Method: Three sequences of A(H3N2) viruses displaying NI contained the following AASs: E119V/E, R292K/R and Q136K/Q (Table S3).


  Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains.
 PMID: 28951584       2017       Scientific reports
Result: This includes the mutations R292K (E1 and V2) and E119V (H1) to name a few.


  Sensitive Detection and Simultaneous Discrimination of Influenza A and B Viruses in Nasopharyngeal Swabs in a Single Assay Using Next-Generation Sequencing-Based Diagnostics.
 PMID: 27658193       2016       PloS one
Discussion: Sequence analysis revealed that the E119V signature mutations in these specimens may be susceptible to oseltamivir in A(H3N2) but not in A(pdH1N1) viruses.


  Detection of reassortant avian influenza A (H11N9) virus in environmental samples from live poultry markets in China.
 PMID: 27268229       2016       Infectious diseases of poverty
Table: E119V


  Human Monoclonal Antibody 81.39a Effectively Neutralizes Emerging Influenza A Viruses of Group 1 and 2 Hemagglutinins.
 PMID: 27630240       2016       Journal of virology
Table: E119V


  Resistance to Mutant Group 2 Influenza Virus Neuraminidases of an Oseltamivir-Zanamivir Hybrid Inhibitor.
 PMID: 27654293       2016       Journal of virology
Abstract: A previous report showed that an N2 E119V/I222L dual mutant conferred drug resistance to seasonal influenza virus.
Abstract: We further elucidate the molecular mechanism underlying N2 drug resistance by solving crystal structures of the N2 E119V and I222L mutants and the dual mutant.


  Risk of resistant avian influenza A virus in wild waterfowl as a result of environmental release of oseltamivir.
 PMID: 27733236       2016       Infection ecology & epidemiology
Introduction: In IAVs containing N1 NA proteins the most common resistance-related change seen in vivo is the framework substitution H274Y (N2 numbering, used hereafter), whereas in N2-containing viruses the framework E119V and active-site R292K substitutions are most commonly described.
Method: In another in vivo mallard model, selection for the framework NA substitution E119V in a low pathogenic A(H5N2) virus was demonstrated when infected ducks were exposed to 1 microg/L of OC in water.
Method: The resistant A(H5N2)/E119V variant dominated the viral population and was transmissible between mallards, but it was outcompeted by wild-type virus when drug exposure was removed.


  Surveillance of antiviral resistance markers in Argentina: detection of E119V neuraminidase mutation in a post-treatment immunocompromised patient.
 PMID: 27849220       2016       Memorias do Instituto Oswaldo Cruz
Abstract: One of the most frequent substitutions in the neuraminidase (NA) protein of influenza A(H3N2) viruses during or soon after oseltamivir administration is E119V mutation.
Abstract: Out of 888 A(H3N2) samples, 842 were tested for the E119V substitution by quantitative RT-PCR: 841 A(H3N2) samples had the wild-type E119 genotype and in one sample, a mixture of viral E119/ V119 subpopulations was detected.
Abstract: We describe the emergence of a mixed viral population with the E119E/V mutation in the NA protein sequence in a post-treatment influenza sample collected from an immunocompromised patient in Argentina.

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