literature

IV mutation literature information.

Profile and generation of reduced neuraminidase inhibitor susceptibility in highly pathogenic avian influenza H7N9 virus from human cases in Mainland of China, 2016-2019.

PMID: 32853849 2020 Virology

Abstract: Passage with zanamivir induced an E119G substitution in NA, whereas passage with oseltamivir induced R292K and E119V substitutions that simulated that seen in oseltamivir -treated HPAI H7N9 cases, indicating that the high frequency of resistant strains in the HPAI H7N9 isolates is related to NAIs use.

Characterization of neuraminidase inhibitor-resistant influenza virus isolates from immunocompromised patients in the Republic of Korea.

PMID: 32631440 2020 Virology journal

Introduction: The typical drug-resistance substitutions in NA include H275Y, E119D/G, and Q136R for A(H1N1)pdm09; E119V, D151G/V/D, R224K, E276D, R292K, and N294S for A (H3N2); and G104E, E117A/D, H134Y, and R150K for B virus, although additional single and combination mutations may also result in NAI drug resistance (World Health Organization (WHO)).

Laninamivir-Interferon Lambda 1 Combination Treatment Promotes Resistance by Influenza A Virus More Rapidly than Laninamivir Alone.

PMID: 32393488 2020 Antimicrobial agents and chemotherapy

Abstract: Moreover, the E119G NA mutation emerged together with concomitant hemagglutinin (HA) mutations (T197A and D222G), which were selected more rapidly by combination treatment with laninamivir plus IFN-lambda1 (passages 2 and 3, respectively) than by laninamivir alone (passage 10).

Abstract: Surprisingly, laninamivir used in combination with IFN-lambda1 promoted the emergence of the E119G NA mutation five passages earlier than laninamivir alone (passage 2 versus passage 7, respectively).

Influenza A/H4N2 mallard infection experiments further indicate zanamivir as less prone to induce environmental resistance development than oseltamivir.

PMID: 31855133 2020 The Journal of general virology

Abstract: Two neuraminidase substitutions emerged, H274N (ZA IC50 increased 5.5-fold) and E119G (ZA IC50 increased 110-fold) at 10 and 100 microg l-1 of ZA, respectively.

Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies.

PMID: 31783761 2019 Virology journal

Table: E119G

Neuraminidase Gene Variations in Influenza A(H1N1)pdm09 Virus among Patients Admitted to Refferal Pulmonary Hospital, Tehran, Iran in 2009-2013.

PMID: 29308074 2017 Tanaffos

Introduction: On the other hand, resistance mutations (H275Y, E119V/G, and I22V) have been reported in in vivo and in vitro models.

Discussion: Also, other known mutations, which cause resistance to NAIs (such as D199N, E119V/G, and I223V/R), were not observed in this study.

Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains.

PMID: 28951584 2017 Scientific reports

Result: Furthermore, E119G mutation will reduce zanamivir susceptibility 1,400-fold, suggesting this anchor could play an important role in designing NA inhibitors for the sialic acid binding site.

Evolution of the neuraminidase gene of seasonal influenza A and B viruses in Thailand between 2010 and 2015.

PMID: 28410396 2017 PloS one

Method: We analyzed for the presence of NA substitutions associated with either NAI-resistant genotype in different NA subtypes (E119V/I/A/G, H274Y, R292K, and N294S: N2 numbering) or reduced susceptibility genotype to NAIs (Q136K, D151E/V/D, D198N/G/E/Y, I222V/T/K/R/M, S246N, E276D, and R371K: N2 numbering) among influenza A and B viruses.

Development of oseltamivir and zanamivir resistance in influenza A(H1N1)pdm09 virus, Denmark, 2014.

PMID: 28128091 2017 Euro surveillance

Abstract: Day 149 when the patient had almost completed the second za

Result: In a sample obtained as BAL there was a higher frequency of the major resistance-inducing mutations (E119G: 35.9%, I223R: 51.8%, and H275Y: 88.2%) compared with a sample obtained as nasopharyngeal swab (E119G: 7.3%, I223R: 34.2% and H275Y:74.9%).

Discussion: The samples were obtained from a nasopharyngeal swab and a BAL, respectively, and the resistance mutation profiles differed, with the BAL sample having a higher frequency of the antiviral resistance mutations E119G, I223R and H275Y, whereas the nasopharyngeal sample, had a low frequency of additional mutations not found in the BAL sample.

A 3D-RISM/RISM study of the oseltamivir binding efficiency with the wild-type and resistance-associated mutant forms of the viral influenza B neuraminidase.

PMID: 26044768 2016 Protein science

Abstract: For E119G and R152K, reduction of the direct drug-target interaction, especially at the mutated residue, is the main source of high-level oseltamivir resistance.

Abstract: The binding affinity of oseltamivir to the influenza B neuraminidase and to its variants with three single substitutions, E119G, R152K, and D198N, is investigated by the MM/3D-RISM method.

Abstract: The theoretical results of the binding affinity of the drug to the mutants reproduced the observed trend in the resistivity, measured by IC50 ; the high-level resistance of E119G and R152K, and the low-level resistance of D198N.

Browser Board

Co-occurred Entities

Filtrator