Genetic sequencing of influenza A (H1N1) pdm09 isolates from South India, collected between 2011 and 2015 to detect mutations affecting virulence and resistance to oseltamivir.
PMID: 33154243
2020
Indian journal of medical microbiology
Abstract: Conclusion: In this study, although H274Y mutation associated with oseltamivir resistance has not been noted, significant mutations have been noted in both HA and NA genes including D239N, N295S, V106I, Q136K, N248D, V267A.
Abstract: Two samples collected from expired patients had D239N (D222G or D225G) mutation in HA.
Epidemiology and full genome sequence analysis of H1N1pdm09 from Northeast China.
Abstract: Three HA amino acid site substitutions occurred at the HA receptor-binding sites and antigenic determinant, including S179N and K180T (located at antigenic site Sa) in A/Tianjinhedong/SWL44/2011(H1) and A/Tianjinjinnan/SWL41/2011(H1), and D239N (located at antigenic site Ca) in A/Tianjinninghe/SWL49/2009(H1).
Molecular evolutionary analysis of pH1N1 2009 influenza virus in Reunion Island, South West Indian Ocean region: a cohort study.
Discussion: Moreover, the D239E variant was found to preferentially colonize the upper respiratory tract, while D239G/N mutants also colonize the lower respiratory tract, hence causing severe acute respiratory syndromes, as is often observed in H5N1 Influenza .
Discussion: Recent studies in hospitalized patients suffering pH1N1 infection have shown that the D239G, D239N and D239E mutations were associated with severe.
Bayesian coalescent analysis of pandemic H1N1 influenza A virus circulating in the South American region.
Abstract: HA substitutions D239G/N and Q310H have been observed only in Brazilian patients.
Abstract: While substitution D239G/N is not particularly associated to a specific genetic lineage, all strains bearing substitution Q310H were assigned to clade 6, suggesting a founder effect.
Mutation analysis of 2009 pandemic influenza A(H1N1) viruses collected in Japan during the peak phase of the pandemic.
Discussion: Mutations of D239G/N (in H1 numbering) have reportedly been associated with severe cases.
Sequence analysis of the 2009 pandemic influenza A H1N1 virus haemagglutinin gene from 2009-2010 Brazilian clinical samples.
PMID: 21894383
2011
Memorias do Instituto Oswaldo Cruz
Abstract: A World Health Organization sequencing protocol allowed us to identify amino acid mutations in the HA protein at positions S220T (71%), D239G/N/S (20%), Y247H (4.5%), E252K (3.3%), M274V (2.2%), Q310H (26.7%) and E391K (12%).
IV mutation literature information.
PMID: 
2020
Indian journal of medical microbiology
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