In silico analysis and molecular characterization of Influenza A (H1N1) pdm09 virus circulating and causing major outbreaks in central India, 2009-2019.
PMID: 33604005
2020
Iranian journal of microbiology
Result: Analysis of amino acid sequence alignment revealed changes at two positions (T151A, D239G) at RBS of HA between genogroup 2 and 3, three positions (A151T, S200P, S202T) between genogroup 3 and 4, two positions (N114D, E279G) between 4 and 6A, four positions (N101S, Q180K, G279E, E300K) between 6A and 6B, three positions (S101N, K180Q, I251V) between 6B and 6C genogroup, four positions (G101S, T214A
Topological N-glycosylation and site-specific N-glycan sulfation of influenza proteins in the highly expressed H1N1 candidate vaccines.
Method: Egg-derived monovalent influenza vaccines derived (inactivated, split virion) from the virus strains of NIBRG-121xp (HA: K136N, D239G; NA: N88G) and NYMC-X181A (HA: K236T, Q240R) were collected as reported previously.
Influenza A H1N1pdm 2009 Virus in Paraguay: Nucleotide Point Mutations in Hemagglutinin and Neuraminidase Genes are not Associated with Drug Resistance.
Abstract: Neither the mutation related to exacerbation of disease (D239G in hemagglutinin) nor that related to antiviral resistance (H275Y in neuraminidase), both detected in neighboring countries, were found.
Introduction: In the HA protein, we did not find the S101N mutation, which is thought to be an adaptation to the human host, or D239E/G, which has been associated with severe clinical outcomes and exacerbate forms of respiratory disease, or N387H, localized at a glycosylation site that could potentially affect the antigenic properties of influenza viruses.
Engineering temperature sensitive live attenuated influenza vaccines from emerging viruses.
Result: There are six amino acid differences (S100P, K136E, A203D, D239G, D293N, and V338I, amino acid positions are based on the use of the start codon and include the signal peptide) between the HA's of rNY1682-viruses and the MDCK propagated FluMist -H1N1pdm LAIV.
Molecular evolutionary analysis of pH1N1 2009 influenza virus in Reunion Island, South West Indian Ocean region: a cohort study.
Discussion: Moreover, the D239E variant was found to preferentially colonize the upper respiratory tract, while D239G/N mutants also colonize the lower respiratory tract, hence causing severe acute respiratory syndromes, as is often observed in H5N1 Influenza .
Discussion: Recent studies in hospitalized patients suffering pH1N1 infection have shown that the D239G, D239N and D239E mutations were associated with severe.
Bayesian coalescent analysis of pandemic H1N1 influenza A virus circulating in the South American region.
Abstract: HA substitutions D239G/N and Q310H have been observed only in Brazilian patients.
Abstract: While substitution D239G/N is not particularly associated to a specific genetic lineage, all strains bearing substitution Q310H were assigned to clade 6, suggesting a founder effect.
Mutation analysis of 2009 pandemic influenza A(H1N1) viruses collected in Japan during the peak phase of the pandemic.
Discussion: Mutations of D239G/N (in H1 numbering) have reportedly been associated with severe cases.
Sequence analysis of the 2009 pandemic influenza A H1N1 virus haemagglutinin gene from 2009-2010 Brazilian clinical samples.
PMID: 21894383
2011
Memorias do Instituto Oswaldo Cruz
Abstract: A World Health Organization sequencing protocol allowed us to identify amino acid mutations in the HA protein at positions S220T (71%), D239G/N/S (20%), Y247H (4.5%), E252K (3.3%), M274V (2.2%), Q310H (26.7%) and E391K (12%).
Abstract: A fatal outcome was associated with the D239G mutation (p < 0.0001).
A new common mutation in the hemagglutinin of the 2009 (H1N1) influenza A virus.
Introduction: PB2-K340N is also of interest as it frequently co-occurred with the potentially virulent HA-D239G mutation but this may also be the reason for its increased occurrence due to a sampling bias towards sequencing more severe cases.
Introduction: For the severe cases, no additional known mutation, such as HA-D239G (D222G or D225G in alternative numberings ), was found that could directly explain severity.
IV mutation literature information.
PMID: 
2020
Iranian journal of microbiology
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