Influenza A H1N1pdm 2009 Virus in Paraguay: Nucleotide Point Mutations in Hemagglutinin and Neuraminidase Genes are not Associated with Drug Resistance.
Introduction: In the HA protein, we did not find the S101N mutation, which is thought to be an adaptation to the human host, or D239E/G, which has been associated with severe clinical outcomes and exacerbate forms of respiratory disease, or N387H, localized at a glycosylation site that could potentially affect the antigenic properties of influenza viruses.
Molecular evolutionary analysis of pH1N1 2009 influenza virus in Reunion Island, South West Indian Ocean region: a cohort study.
1Abstract: PRINCIPAL FINDINGS: We found that i) Reunion pH1N1 sequences stemmed from global ""clade 7"" but shaped two phylogenetic sub-clades; ii) D239E mutation was identified in the hemagglutinin protein of all Reunion sequences, a mutation which has been associated elsewhere with mild-, upper-respiratory tract pH1N1 infecting strains; iii) Date estimates from molecular phylogenies predicted clade emergence some time before the first detection of pH1N1 by the epidemiological surveillance system; iv) Phylogenetic relatedness was observed between Reunion pH1N1 viruses and those from other countries in South-western Indian Ocean area; v) Quasispecies populations were observed within households and individuals of the cohort-study."
Result: All clade RUN sequences also exhibited a fixed amino acid mutation in HA (D239E) and a silent mutation in PMID: 21572517
2011
PloS one
Discussion: Instead, a D239E mutation was found in three samples (Table 2).
IV mutation literature information.
PMID: 
2014
The open virology journal
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