literature

IV mutation literature information.

[H1N1V influenza epidemic of 2009 in Russia].

PMID: 21899089 2011 Vestnik Rossiiskoi akademii meditsinskikh nauk

Abstract: 26.7% of the viral isolates obtained in the end of the epidemic had D222G substitution responsible for tropism of viruses to lung tissues.

[Analysis of pandemic influenza in Russia as a part of the global process based on data of an influenza monitoring reference center].

PMID: 21809641 2011 Zhurnal mikrobiologii, epidemiologii i immunobiologii

Abstract: A number of strains contained D222G mutation that is responsible for the expansion of substrate specificity, as well as strain specific substitutions in hemagglutinin and neuraminidase molecules.

[The 2009 pandemic influenza in Russia. I. Diagnosis and molecular biological characteristics of the virus].

PMID: 21427949 2011 Voprosy virusologii

Abstract: The substitution of amino acid residue of Asp to Gly at position 222 of HA was found in 8 (73%) of 11 isolates from postmortem lung and trachea samples and in 2 (10%) of 20 isolates from nasopharyngeal swabs.

Nationwide molecular surveillance of pandemic H1N1 influenza A virus genomes: Canada, 2009.

PMID: 21249207 2011 PloS one

Result: Only six coding substitutions were observed within the HA receptor-binding site (RBS): one A186T variant in the 190-helix (184-191); and 5 residue 222 variants (D222E and D222G) in the 220-loop (mature peptide residues 218-225).

Result: When analysis of positive selection was conducted, only two viral sites located in HA (namely D222G/E and E374K) displayed evidence of adaptive evolution, corresponding to the HA RBS and HA2-subunit position 47, respectively.

Discussion: And despite the fact that A/H1N1pdm HA D222E/G (and N) variant viruses have been detected in fatal cases,

A new common mutation in the hemagglutinin of the 2009 (H1N1) influenza A virus.

PMID: 20535229 2010 PLoS currents

Introduction: For the severe cases, no additional known mutation, such as HA-D239G (D222G or D225G in alternative numberings ), was found that could directly explain severity.

[A possible association of fatal pneumonia with mutations of pandemic influenza A/H1N1 sw1 virus in the receptor-binding site of the HA1 subunit].

PMID: 20886705 2010 Voprosy virusologii

Abstract: 70% of the primary materials from the deceased patients were found to have pandemic influenza A(H1N1) v mutants in the lung tissue with D222G (15%), D222N (15%), D222E (2%) substitutions, as well as a mixture of mutants (38%).

Abstract: Preliminary data from the study of the interaction of the hemagglutinin of two strains having D222G and D222N mutations with 9 oligosaccharides imitating the variants of cell receptors for influenza A virus suggest that there is a double receptor specificity for alpha2'-3' and alpha2'-6'-sialosides with a preponderance of alpha2'-3'-specificity.

Evaluation of HA-D222G/N polymorphism using targeted NGS analysis in A(H1N1)pdm09 influenza virus in Russia in 2018-2019.

PMID: 20826688 2010 Journal of virology

Abstract: An Asp222Gly (D222G) substitution has been associated with severe or fatal disease.

[Detection of amino acid substitutions of asparaginic acid for glycine and asparagine at the receptor-binding site of hemagglutinin in the variants of pandemic influenza A/H1N1 virus from patients with fatal outcome and moderate form of the disease].

PMID: 20608076 2010 Voprosy virusologii

Abstract: In one patient with the moderate form of the disease, D222G mutation was revealed after the second passage in the developing chick embryos; this mutation was not found in the primary sample from the patient.

Abstract: This site exhibited mutations in 9 samples: D222G (n=3), D222N (n=3), and D222G/D222N (n=3).

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