Result: When analysis of positive selection was conducted, only two viral sites located in HA (namely D222G/E and E374K) displayed evidence of adaptive evolution, corresponding to the
Discussion: And despite the fact that A/H1N1pdm HA D222E/G (and N) variant viruses have been detected in fatal cases, the same mutation also has been detected globally in mild A/H1N1pdm cases; conversely, viruses from numerous fatal cases lack the mutation.
Discussion: For example, HA D222E/G/N (also called 239) and HA Q293H (also called 310) mutant viruses have been isolated worldwide from fatal laboratory-confirmed A/H1N1pdm cases.
Genetic structure of human A/H1N1 and A/H3N2 influenza virus on Corsica Island: phylogenetic analysis and vaccine strain match, 2006-2010.
Result: We calculated the antigenic distance from the vaccine strain of the Northern Hemisphere in 2009-2010, A/California/7/2009 and the A/H1N1pdm strains having the substitution
Discussion: Overrepresentation of certain mutations among geographically and temporally related samples needs to be carefully controlled for possible founder effects which could be identified as homogenous clusters in phylogenetic analyses, as was observed to be the case for the D222E mutation.
Discussion: Phylogenetic analysis of A/H1N1pdm influenza viruses showed that viruses isolated in Corsica Island formed a separate sub-clade of clade 7 as a consequence of the presence of the D222E substitution.
Discussion: Recently, a cluster of D222E viruses among school children was isolated in Italy, confirming human-to-human transmission of viruses mutated at amino acid position 222.
[Cuban strategy for the molecular characterization of the pandemic influenza A virus (H1N1)].
PMID: 23437533
2011
Revista cubana de medicina tropical
Abstract: RESULTS: The third strategy provided the most comprehensive results such as differential diagnosis, the surveillance of the D222G/E mutation in hemagglutinin and Tamiflu-resistant H275Y viral variants.
Epidemiological, demographic, and molecular characteristics of laboratory-confirmed pandemic influenza A (H1N1) virus infection in Turkey, May 15-November 30, 2009.
PMID: 20657062
2010
Japanese journal of infectious diseases
Abstract: More than 37% of the isolates had mutation at position D222E/N on HA gene.
[A possible association of fatal pneumonia with mutations of pandemic influenza A/H1N1 sw1 virus in the receptor-binding site of the HA1 subunit].
Abstract: 70% of the primary materials from the deceased patients were found to have pandemic influenza A(H1N1) v mutants in the lung tissue with D222G (15%), D222N (15%), D222E (2%) substitutions, as well as a mixture of mutants (38%).
IV mutation literature information.
PMID: 
2011
PloS one
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