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 IV mutation literature information.


  Virological characterization of influenza H1N1pdm09 in Vietnam, 2010-2013.
 PMID: 25966032       2015       Influenza and other respiratory viruses
Introduction: For example, the amino acid substitution at position D222G/E/N (H1 numbering) in the HA molecule was associated with increased viremia, severe pneumonia, and deaths; a substitution (I219K) in the glycan receptor-binding site of HA quantitatively increased its human receptor-binding affinity; and substitutions D131E, S186, and A198E contribute to virulence in mice.


  Antibody pressure by a human monoclonal antibody targeting the 2009 pandemic H1N1 virus hemagglutinin drives the emergence of a virus with increased virulence in mice.
 PMID: 22647789       2012       mBio
Abstract: Six substitutions greatly reduced MAb binding (K123N, D131E, K133T, G134S, K157N, and G158E).



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