Result: Prophylactic and therapeutic studies were performed to explore the protection efficacy of both Z2B3 and Z2B3-D102R against challenge with different viruses in vivo.
Result: The NA inhibition ability of Z2B3 and Z2B
Result: The MUNANA-based NA inhibition assay showed that both Z2B3 and Z2B3-D102R inhibit NA activity of the 18N1 protein, with 50% inhibitory concentrations (IC50s) of 118 and 386 nM, respectively.
Result: The complex structure of Serbia N1 and Z2B3-D102R further demonstrated that a salt bridge was formed between the E432 of Serbia N1 and R102 of Z2B3-D102R as expected.
Result: Z2B3-D102R dramatically restored inhibition activity to Serbia N1, with an IC50 of 116 nM.
IV mutation literature information.
PMID: 
2020
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