[Change of phenotypic properties of escape mutants and readaptants of influenza virus A (H1N1)pdm09 under the influence of selected mutations in the molecule of hemagglutinin.]
Abstract: Our potential antigenic variants, except readapted variant, which contained A198E mutation, did not reach fixation in infected people.
Abstract: Several amino acid substitutions, including K163 N, Q192 L, D190E, G228E, and K285 M, reduced the stability of HA as determined by heat inactivation, whereas A198E substitution is associated with significant increase in HA thermostability compared to the wild-type virus.
Virological characterization of influenza H1N1pdm09 in Vietnam, 2010-2013.
PMID: 25966032
2015
Influenza and other respiratory viruses
Introduction: For example, the amino acid substitution at position D222G/E/N (H1 numbering) in the HA molecule was associated with increased viremia, severe pneumonia, and deaths; a substitution (I219K) in the glycan receptor-binding site of HA quantitatively increased its human receptor-binding affinity; and substitutions D131E, S186, and A198E contribute to virulence in mice.
Immunodominance with progenitor B cell diversity in the neutralizing antibody repertoire to influenza infection.
Abstract: A majority of mAb, established from individual BALB/c (H-2d) mice, select mutant viruses containing the same single amino acid substitution in the membrane distal ecto-domain, HA1 198 A-->E, whereas changes at either HA1 158 G-->E or HA1 198 A-->E are selected for by mAb from BALB.K (H-2k) donors.
IV mutation literature information.
PMID: 
2019
Voprosy virusologii
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