Result: Aligned with SH2 HA, GD17 HA has 12 amino acid substitutions in addition to the insertion of the multibasic cleavage site, including S127N in antigenic site A, L226Q in the receptor-binding site (RBS) and antigenic site D, and A134V that was attributed to antigenic drift.
[Genetic characteristics of hemagglutinin and neuraminidase of avian influenza A (H7N9) virus in Guizhou province, 2014-2017].
PMID: 30462955
2018
Zhonghua liu xing bing xue za zhi
Abstract: Mutations A134V, G186V and Q226L at the receptor binding sites were found in the HA.
Neuraminidase inhibitor sensitivity and receptor-binding specificity of Cambodian clade 1 highly pathogenic H5N1 influenza virus.
PMID: 21343450
2011
Antimicrobial agents and chemotherapy
Abstract: We also identified a virus with a hemagglutinin A134V mutation, present in a subpopulation amplified directly from a human sample.
Prediction of avian influenza A binding preference to human receptor using conformational analysis of receptor bound to hemagglutinin.
Abstract: RESULTS: Molecular dynamics simulation was employed to study the interactions between receptor models and hemagglutinin proteins from H5N1 strains A/Duck/Singapore/3/97, mutated A/Duck/Singapore/3/97 (Q222L, G224S, Q222L/G224S), A/Thailand/1(KAN-1)/2004, and mutated A/Thailand/1(KAN-1)/2004 (L129V/A134V).
Introduction: A Kan-1 derived strain with further HA mutations L129V and A134V is considered a quasi-species which exhibited higher selectivity toward human cell type receptor.
Result: In contrast, the cis conformation was observed (Phi = +60 degrees) for the majority of the simulation time when the analogs bound with Puer
IV mutation literature information.
PMID: 
2019
Journal of virology
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