Stability of the HTLV-1 glycoprotein 46 (gp46) gene in an endemic region of the Brazilian Amazon and the presence of a significant mutation (N93D) in symptomatic patients.
Result: Just over half (52.5%; 21) of the 40 samples analyzed in this study presented some type of amino acid mutation, with three types - S72G, N93D and S192P - being recorded most frequently (Table 3).
Result: Six of the 40 samples analyzed in the present study were diagnosed with HAM/TSP, of which, two presented amino acid mutations (one patient with S72G and the other with both L70I and S103P).
Result: The mutations S72G and N93D were each identified in five samples (23.8% of the total).
Result: Three of the five individuals with the S72G mutation were symptomatic, one with
HTLV1 mutation literature information.
PMID: 
2018
Virology journal
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