Stability of the HTLV-1 glycoprotein 46 (gp46) gene in an endemic region of the Brazilian Amazon and the presence of a significant mutation (N93D) in symptomatic patients.
Discussion: In the present study, 21 of the samples presented amino acid mutations, of which, S35 L, F14S, and S72G have been described previously, and most are associated with specific functional domains.
Molecular characterization of HTLV-1 gp46 glycoprotein from health carriers and HAM/TSP infected individuals.
Abstract: A single amino acid (aa) substitution (S35L) was exclusive for the HC group, and three gp46 substitutions (F14S, N42H, G72S) were exclusive for the HAM/TSP group.
Result: After submission of wild type and mutated sequences to SWISS-MODEL server, the results showed that the S35L and G72S mutations were associated to the change of coil for extended beta at the secondary structure prediction (Figure 5).
Result: Among the five mutations found, three (F14S, S35L and N42H) were not present in any of the 42 Brazilian sequences used to create the co
HTLV1 mutation literature information.
PMID: 
2018
Virology journal
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